Predictive Values of Presepsin Levels in ASciteS in Patients With Chronic Liver Failure
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Mortality at 6 months
研究概览
简要总结
The investigators aim to study the predictive value of presepsin in ascites in newly admitted patients with chronic liver failure.
详细描述
Presepsin is a plasmatic cleaved fragment of CD14. CD14 is a toll like receptor who has the role to identify certain lipopolysaccharides on the surface of bacteria (aerobes and anaerobes), thus promoting an inflammatory response.
A study of 153 patients with liver cirrhosis published by a team of investigators from Iasi, Romania, has proven an useful role of plasma presepsin in early diagnosis of infections in patients in acute on chronic liver failure.
In addition, plasma presepsin has been proposed as an independent predictor of mortality in patients with decompensated liver cirrhosis, without concomitant bacterial infections.
Question to be answered by this study The investigators aim to evaluate the predictive role of ascites presepsin in patients with chronic liver failure.
Hypothesis Presepsin levels in ascites may have a prognostic role in patients with ascites and chronic liver failure.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patient with ascites and chronic liver failure
- •no contraindications and technical possibility to perform diagnostic paracentesis
- •age above 18 years old
- •informed consent
排除标准
- •contraindications to paracentesis or technical impossibility to perform paracentesis
- •absence of informed consent
结局指标
主要结局
Mortality at 6 months
时间窗: 6 months
Number of who deceased during admission or during the 180 days after admission divided by the number of patients who were admitted. An analysis will be done to see if the presepsin levels are predictive for this event.
次要结局
- Spontaneous bacterial peritonitis (SBP) rate(6 months)
- Hepatic encephalopathy rate(6 months)
- Any infection rate(6 months)
研究者
Mihai Ciocirlan
Associate Professor of Gastroenterology
Carol Davila University of Medicine and Pharmacy