Intestinal Microbiota, Tryptophan and Autism
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Autism Spectrum Disorder
- Sponsor
- University Hospital, Tours
- Enrollment
- 66
- Locations
- 2
- Primary Endpoint
- Urinary concentrations of tryptophan metabolites
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Autism Spectrum Disorder refers to complex neuro-developmental disorders that affect social communication and behavioral adaptation. Currently, the diagnosis of Autism Spectrum Disorder is based on a clinical examination that is performed classically during the first three years of life. The heterogeneity of the disorders occurring in autism make pathologies difficult to diagnose and manage.
The overall goal of this project is the identification of metabolic biomarkers based on clinical profile. The best characterization of physiopathological pathways will ultimately allow the identification of subgroups of subjects and facilitate the development of targeted therapeutics.
The proposed work aims to test the hypothesis of a disruption of tryptophan metabolism in Autism Spectrum Disorder via the gut microbiota.
Detailed Description
Autism Spectrum Disorder refers to complex neuro-developmental disorders that affect social communication and behavioral adaptation. In France, Autism Spectrum Disorderaffects about 1 in 100 people according to international criteria and is diagnosed in early childhood. Currently, the diagnosis of Autism Spectrum Disorder is based on a clinical examination that is performed classically during the first three years of life. The heterogeneity of the disorders occurring in autism make pathologies difficult to diagnose and manage. The overall goal of this project is the identification of metabolic biomarkers based on clinical profile (based on behavioral and cognitive markers). The best characterization of physiopathological pathways (from the molecular scale to the phenotypic scale) will ultimately allow the identification of subgroups of subjects and facilitate the development of targeted therapeutics. The proposed work aims to test the hypothesis of a disruption of tryptophan metabolism in Autism Spectrum Disorder via the gut microbiota.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Urinary concentrations of tryptophan metabolites
Time Frame: At baseline
Quantification by High-Performance Liquid Chromatography and Mass Spectrometry
Faecal concentrations of tryptophan metabolites
Time Frame: At baseline
Quantification by using High-Performance Liquid Chromatography and Mass Spectrometry
Secondary Outcomes
- Characterization of gut microbiota(At baseline)
- Correlation of metabolic profiles of tryptophan and microbiotic profiles(At baseline)