Neuromuscular Control in Knee Osteoarthritis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 95
- 试验地点
- 1
- 主要终点
- Neuromuscular Control
研究概览
简要总结
Arthritis is one of the most prevailing causes of disability with knee osteoarthritis (KOA) the most common form. The lifetime risk of developing symptomatic KOA by the age of 85 years is 44.7%, where females are at a greater risk (1.8 times) than male counter parts. KOA is the leading cause of limitations in activities of daily living such as walking and climbing stairs particularly in the elderly. This is primarily due to pain and instability of the joint resulting in buckling of knees caused by muscle weakness, joint stiffness and damage. Patients with KOA have larger variations in muscle strength and are unable to maintain a target force combined with impaired ability to perceive joint movement and positioning suggests impaired neuromuscular control (NC) may influence KOA. NC refers to the nervous system's control over muscle activation contributing to task performance. This study aims to establish the role of loss of NC in biomechanical determinants and health outcomes of KOA.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Knee osteoarthritis participants only:
- •Knee Osteoarthritis confirmed by a physician using the American College of Rheumatology (ACR 1986) Criteria
- •Have unilateral or bilateral knee osteoarthritis
- •Aged 40 years or over.
- •Healthy control participants only:
- •Have no history of unilateral/bilateral knee osteoarthritis
- •Had no current chronic/stable knee pain in the past 3 months
- •Aged 40 years or over.
排除标准
- •All participants are excluded if they:
- •Have neuromuscular skeletal injury/illness (e.g.Multiple Sclerosis, Parkinson's disease, Muscular Dystrophy, Cerebral Palsy)
- •Have had knee surgery, knee arthroplastic surgery and arthroscopic debridement or corrective surgery for knee osteoarthritis in the past 12 months
- •Have had corticosteroid injections to or around the knee in the past 3 months.
- •Have unstable heart disease
- •Previously had a stroke
- •Have insulin-dependent diabetes
- •Have osteoporosis
- •Have a history of falls and other motor deficits
- •Are unable to walk up and down stairs
- •Are unable to rise from a chair without the aid of another person
- •Have an unstable medication schedule and medication that causes dizziness
- •Have Dementia/Alzheimer's/ an inability to comprehend, follow instructions and give informed consent
- •Have an inability to lie flat for 60 minutes Have mental in their body.
结局指标
主要结局
Neuromuscular Control
时间窗: 1 day
Neuromuscular control will be assessed through muscle co-activation index from electromyography (EMG) of the hamstrings, quadriceps and gastrocnemius. The electromechanical delay (delay between the onset of EMG and force), active proprioception and force accuracy and steadiness measure determined from submaximal isometric contractions will be used to determine neuromuscular control
次要结局
- Disease Outcome(1 day)
研究者
Martijn Steultjens
Professor of Musculoskeletal Health
Glasgow Caledonian University