Investigation of Clinical Effectiveness of Propolis Extracts as Food Supplements in Patients With SARS-CoV-2(COVID-19)
- Conditions
- SARS-CoV2 Infection
- Interventions
- Dietary Supplement: propolis
- Registration Number
- NCT04916821
- Lead Sponsor
- Trabzon Kanuni Education and Research Hospital
- Brief Summary
Primary purpose: To investigate the effect of propolis, a food supplement product, on healing parameters in patients with COVID 19. Secondary purpose: To provide a new supportive treatment in Covid 19 treatment. In the present study to examine the effect of the use of propolis on healing parameters (laboratory and imaging) in patients with COVID 19; Propolis, which has antiviral properties, has also been used in humans in the COVID19 pandemic as of 2020. However, in these studies, an alcohol-soluble extract of propolis was used. Despite the disadvantages of its use in alcohol, it is clear that water and olive oil extracts of Propolis are safer for humans. Therefore, water extracts of propolis will be used in the study.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 45
- Patients over the age of 18 who do not need a ventilator who are inpatient in the Covid service
- Patients under the age of 60 who do not need a ventilator who are inpatient in the Covid service
- patients do not have oral intake
- patients whose informed consent form is not approved
- patients who need a ventilator
- pregnant women
- children
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description water extract of propolis propolis Patients given 2 ml of aqueous propolis extract (50mg / ml) orally 3 times a day for 1 week olive oil extract of propolis including perga propolis Patients given 1 ml oily propolis extract (64 mg / ml) + 1 ml oily perga extract (120 mg / ml) orally 3 times a day for 1 week
- Primary Outcome Measures
Name Time Method laboratory parameters-4: D-Dimer Change from Baseline D-Dimer findings at one week D-Dimer
radiological Change from Baseline Lung Tomography Findings(Peripheral ground-glass opacities) at one week Lung tomography findings
laboratory parameters-2: ESR Change from Baseline ESR findings at one week ESR
laboratory parameters-3: CRP Change from Baseline CRP findings at one week CRP
laboratory parameters-5: Troponin Change from Baseline Troponin findings at one week Troponin
laboratory parameters-6: sO2 Change from Baseline sO2 findings at one week sO2
laboratory parameters-1: CBC Change from Baseline CBC findings at one week CBC
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Trabzon Faculty of Medicine , Health Science University
🇹🇷Trabzon, Turkey