Comparative Effects on Diaphragmatic Electrical Activity and Respiratory Pattern of Various Levels of Assistance in Pressure Support and in Neurally Adjusted Ventilatory Assist
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 发起方
- 入组人数
- 2
- 试验地点
- 2
- 主要终点
- Electrical diaphragmatic signal variations and ventilatory profile variations under various level of assistance
研究概览
简要总结
Exploration of the effects on diaphragmatic electrical activity (EMG) and on respiratory pattern of various level of assistance delivered by the ventilator in intubated spontaneously breathing patients in pressure support (PS) and in Neurally Adjusted Ventilatory Assist (NAVA) by step by step increasing of the level of assistance. Flow, airway pressure, transesophageal EMG signal and transcutaneous EMG signal will be recorded.
详细描述
Exploration of the effects on diaphragmatic electrical activity (EMG) and on respiratory pattern of various level of assistance delivered by the ventilator in intubated spontaneously breathing patients in pressure support (PS) and in Neurally Adjusted Ventilatory Assist (NAVA) by step by step increasing of the level of assistance. Flow, airway pressure, transesophageal EMG signal and transcutaneous EMG signal will be recorded.
Aims of the study:
- To study the electrical diaphragmatic signal variations and the ventilatory profile variations under various level of assistance (delivered by the ventilator) in PS and in NAVA in intubated spontaneously breathing patients
- To compare a non invasive technique of diaphragmatic electrical activity recording under various levels of assistance with the invasive reference technique
研究设计
- 研究类型
- Interventional
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •- Patients admitted to the ICU, intubated for acute respiratory failure, and ventilated in PS mode will be eligible for inclusion in the study.
排除标准
- •Severe hypoxemia requiring an FIO2 > 0.5
- •hemodynamic instability (defined as the need for high doses of catecholamines namely ≥ 0.5 μg/kg min- and/or high need in volume resuscitation namely more than two litres of crystalloids in two hours-)
- •oesophageal problem such as hiatal hernia, oesophageal varicosities, oesophageal surgery;
- •active upper gastro-intestinal bleeding;
- •known coagulation disorder;
- •any other contraindication to the insertion of a naso-gastric tube;
- •poor short term prognosis (death expected within the next seven days)
- •age < 18 years old.
结局指标
主要结局
Electrical diaphragmatic signal variations and ventilatory profile variations under various level of assistance
To study the electrical diaphragmatic signal variations and the ventilatory profile variations under various level of assistance (delivered by the ventilator) in Pressure and in Neurally adjusted ventilatory assist in intubated spontaneously breathing patients
次要结局
- Compare a non invasive technique of diaphragmatic electrical activity recording under various levels of assistance with the invasive reference technique.
研究者
Prof. Philippe Jolliet
Main investigator
University of Lausanne Hospitals