eural correlates of chronic fatigue syndrome
Completed
- Conditions
- chronic fatigue syndrome
- Registration Number
- NL-OMON20349
- Lead Sponsor
- Donders Institute for neuroimaging, Radboud University NijmegenExpert Centre for Chronic fatigue, Radboud UMC Nijmegen
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
• ≥ 18 years ≤ 65 years;
• Women;
Exclusion Criteria
• Any injury to the right hand that confounds hand grip performance;
• A maximal voluntary contraction (MVC) that exceeds the maximal dispersion of the hand grip device (>400
Newton)
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method - Blood Oxygenation Level Dependent (BOLD) signal as measured with functional Magnetic Resonance Imaging (fMRI)<br /><br>- Cerebral tissue properties as measured with Magnetic Resonance Imaging (MRI), Diffusion Tensor Imaging (DTI) and MR-spectroscopy.<br /><br>- Behavioural performance on computerized tasks<br /><br>- Fatigue severity: checklist individual strength (CIS)<br /><br><br> <br>
- Secondary Outcome Measures
Name Time Method - Subjective measurements, e.g. self-report questionnaires, visual analogue scales <br /><br>- NAA concentration as determined by MR-spectroscopy<br /><br>- Cortisol and cytokine protein concentrations from hair, saliva and blood samples