Evaluation of the effect of orthokine on histological and radiographic characteristics of hard tissue after Horizontal Bone Augmentation and Socket Preservation surgery

Phase 3

• Conditions: Condition 1: Horizontal Bone Augmentation. Condition 2: Socket preservation.

• Registration Number: IRCT20180905040955N2
• Lead Sponsor: Tabriz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 11 January 2022

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

The difficulty of surgery is the same compared to the other side based on the dimensions required for augmentation as well as the condition of the existing tooth before extraction and the condition of the ridge.
Patients should require implant placement in site
patients should be satisfied for surgery.

Exclusion Criteria

presence of systemic diseases
presence of history of using disruptive drugs in healing processes
The patient does not want to have surgery
Presence of metabolic bone diseases

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The amount of collagen. Timepoint: 4 months after surgery. Method of measurement: Hematoxylin and eosin staining and TRAP, histological slide examination.;Alkaline phosphatase activity. Timepoint: 4 months after surgery. Method of measurement: MultiSkanGo plate reader software.;Issue mineralization rate. Timepoint: 4 months after surgery. Method of measurement: Investigation of mineralized areas in histological slide examination.;Number of cells per unit area. Timepoint: 4 months after surgery. Method of measurement: Histological slide examination and MutikImage 2 software.;Gene expansion. Timepoint: 4 months after surgery. Method of measurement: Reverse transcription PCR.;Horizontal dimension of bone. Timepoint: 4 months after surgery. Method of measurement: Calculation from CBCT radiography.;Hansfield number. Timepoint: 4 months after surgery. Method of measurement: Calculation from CBCT radiography.