Evaluation of shukra-vardhana effect of shivalingi beej(Bryonia laciniosa L.) in the management of kshina- shukra or oligospermia in adult Males : A randomised double arm double blinded placebo control clinical trial.

Sexual health is an important aspect of every individual. Problems related to sexual health remain serious issue, particularly in young adults Infertility affects an estimated 15% of couples globally, amounting to 4KS million couples. The calculated global data shows that the percentage of infertility that is attributable to males ranged between 20.20%, and that the percentage of infertile men ranged from 2-5% to 12%, WHO estimate the overall prevalence of primary infertility in India is between 3,9 to 16.8 Indian states prevalence of infertility varies from state to suite such a 37 per cent in Uttar Pradesh, Himachal Pradesh and Maharashtra, so per cent in Andhra Pradesh and 15 per com in Kashmir and prevalence varies in same region across

tribes and caste.

There is a regional variation in the prevalence of anospermia and oligozoospermia in the male partners of infertile couples from different reations of India. The prevalence of azospermia is extremely high in Kurnool and lodhpur (38.3% and 37.4%, respectively). There is also a regional variation in the prevalence of oligozoospermia (31%) in Kurnool

Ayurvedic classics have mentioned that the reproduction is the work of Shidra dhatu, kahina shikra is one of the eight types of Shukradhushti mentioned in the classics. Various drugs have been mentioned in Aurveda classics which act on Kshina-shukru. The drug Shivalingi is mentioned in raj nighantu as rasayani and sarv-siddhikara. The reference of Shivalingi found in In Bhavprakash Samhita for vandhyarva chikitsa as the seeds of Shivalingi are taken with milk which provide male progeny to pregnant mother. Shivalingi belongs to group of valuable drugs in the area of therapeutics of sterility and infertility disorders.

In modern medicines the conditions associated with Kshina-Shukra in ayurveda can be well matched with Oilgospermia. In this condition the sperm count comes below 15 milli/ml." According to ethnomedicinal review Shivalingi have aphrodisiac and -spermatogenic effect. The drug selected for this work is Shivalingi Beej (Bryonia laciniosa L.) and the drug is already evaluated for its Physicochemical, phytochemical study and pre-clinical study but the clinical study has not been conducted yet.

Considering this, present study has been undertaken to evaluate the Shukra vardhan Efecct of Shivalingi Beej