The Clinical and Prognostic Features of PRES

Completed

• Conditions: Pregnancy Outcomes; Preeclampsia; Posterior Reversible Encephalopathy Syndrome; Eclampsia
• Interventions: Diagnostic Test: PRES in PE or E

• Registration Number: NCT05143710
• Lead Sponsor: Dunjin Chen

Brief Summary

The purpose of this study is to determine the features of clinical imaging, disease severity and pregnancy outcomes in posterior reversible encephalopathy syndrome with preeclampsia or eclampsia.

Detailed Description

The investigators retrospectively collected data (General information, clinical data, biochemical indicators, imaging features, and pregnancy outcome) from pregnant woman diagnosed with PRES with preeclampsia or eclampsia to analyze features of clinical imaging, disease severity and pregnancy outcomes during 2012 to 2021.Then, the investigators grouped all the patients into early onset group and late onset PE group according to gestational weeks to analyze differences of clinical imaging. Finally, the investigators grouped all the patients into good pregnancy outcomes group and poor pregnancy outcomes group according to diagnostic criteria, including the incidence of stillbirth and premature birth, to analyze differences of clinical imaging .

Study Timeline

• Study Start: 2020-10-01
• Study First Submitted: 2021-11-10
• Study First Submitted QC: 2021-11-21
• Study First Posted: 2021-12-03
• Primary Completion: 2022-01-31
• Study Completion: 2022-01-31
• Status Verified: 2022-02
• Last Update Submitted: 2022-02-28
• Last Update Posted: 2022-03-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 354

Inclusion Criteria

1. patients were diagnosed of PRES with PE or E
2. all patients provided written informed consent

Exclusion Criteria

1. patients combined with other neurological disorders
2. patients combined with mental illness

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
PRES in PE or E	PRES in PE or E	patients diagnosed with PRES in PE or E

Primary Outcome Measures

Name	Time	Method
biochemical parameters	Biochemical indicators were collected within 1 week of the hospital stay.	The PRES patients may have a lower level of serum albumin (﹤35g/L) ,and have a higher level of lactic dehydrogenase (﹥380U/L).
features of clinical imaging	Cranial Imaging was examined immediately at the onset of symptoms, such as s headaches, visual changes, seizures, consciousness impairment, mental disorders, and focal neurological deficits.	The imaging features were described by their location including frontal, parietal, occipital, temporal, cerebellum, basal ganglia, brain stem, deep white matter and callosum, and 1 point was recorded for each location involved.
blood pressure(BP)	The BP of patients was obtained immediately at the onset of symptoms.	hypertension：≥140/90mmHg
pregnancy outcomes	From day of admission until the day of discharge or date of death from any cause,whichever came first,assessed up to 1 year.	The PRES patients may have longer time of hospitalization.

Trial Locations

Locations (1)

Department of Obstetrics and Gynecology, Key Laboratory for Major Obstetric Diseases of Guangdong Province, The Third Affiliated Hospital of Guangzhou Medical University; 🇨🇳 Guangzhou, China