NCT03188900已完成不适用
New Therapeutic Strategy Against Preeclampsia: Angiogenic Switch to Physiological State by Extracorporeal Removal of sFlt-1
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 236
- 试验地点
- 1
- 主要终点
- ratio sFlt-1/PlGF
研究概览
简要总结
The aim of the study is to setup a collection of maternal plasma and serum from patients with preeclampsia and normal pregnancy for in vitro validation of new therapeutics based on extra-corporal removal of sFlt-1
详细描述
A collection of maternal plasma and serum from patients with preeclampsia (PE) and normal pregnancy (NP) :
- Between 20WG and 23WG+6D : 20 patients with PE and 30 patients with NP
- Between 24WG and 27WG+6D : 20 patients with PE and 30 patients with NP
- Between 28WG and 31WG+6D : 20 patients with PE and 30 patients with NP
- Between 32WG and 35WG+6D : 20 patients with PE and 30 patients with NP
- Between 36WG and 40WG+6D : 20 patients with PE and 30 patients with NP
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Age from 18 to 50 years old
- •Singleton pregnancies between 20 and 41 weeks of gestation
- •Preeclampsia
- •Normal pregnancy
排除标准
- •Infectious disease: HIV, HBV or HCV
- •Multiple pregnancies
- •Opposition of the patient
结局指标
主要结局
ratio sFlt-1/PlGF
时间窗: Day 0
measurement of of sFlT-1 and PlGF
次要结局
- Kinetics of these ratios sFlt-1/PlGF during pregnancy(until 5 month)
研究者
研究点 (1)
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