Double-Blind, Placebo-Controlled Trial of Pioglitazone for Bipolar Depression
试验速览
- 阶段
- 4 期
- 状态
- 终止
- 入组人数
- 37
- 试验地点
- 1
- 主要终点
- Change in Inventory of Depressive Symptomatology-Clinician Rated (IDS-C30) Total Score
研究概览
简要总结
The primary objective is to test the hypothesis that adjunctive pioglitazone is more effective than placebo for the relief of acute depressive symptoms resulting from bipolar disorder. The secondary objectives are to determine potential moderators and mediators of antidepressant efficacy.
详细描述
The study is a double-blind, placebo-controlled 8-week trial of pioglitazone, either as monotherapy or adjunctive to a mood stabilizer, for the acute relief of bipolar depression. The enrollment goal is 80 subjects (40 patients each in the pioglitazone treatment group and the placebo treatment group).
Screening Phase: Patients who have been prescribed a mood stabilizer for > 4 weeks and are on a therapeutic dose will proceed directly to the Screening Visit. For situations in which the patient prefers to be taking a mood stabilizer or where the treating psychiatrist feels it is clinically necessary, a mood stabilizer (lithium, divalproex, carbamazepine, lamotrigine, olanzapine, quetiapine, risperidone, aripiprazole, ziprasidone or lurasidone) will be initiated (see Mood Stabilizer Initiation section below). For this set of patients who do begin a mood stabilizer, the Screening Phase may last up to 8 weeks. Otherwise, subjects who do not come in on a mood stabilizer will proceed directly to screening.
Double-Blind, Placebo-Controlled Study Period (Week 1 to Week 8): Patients who meet inclusion/exclusion criteria will be randomized to study treatment at the baseline/randomization visit within 30 days of the screening visit. The efficacy and safety assessments will be carried out at baseline/randomization and then weekly or every two weeks for a total of 8 weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Be male or female >= 18 years of age
- •Diagnostic and Statistical Manual-IV (DSM-IV) diagnosis of bipolar disorder (type I, II, or NOS)
- •Currently depressed as confirmed by the Mini-International Neuropsychiatric Interview (M.I.N.I.)-Plus at the screening visit
- •Inventory of Depressive Symptoms total score > 25 or Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR16) > 11 at study baseline
- •Women of childbearing potential (not surgically sterile or 2 years postmenopausal), must use a medically accepted method of contraception and must agree to continue use of this method for the duration of the study and for 30 days after participation in the study. Acceptable methods of contraception include barrier method with spermicide, abstinence, intrauterine device (IUD), or steroidal contraceptive (oral, transdermal, implanted, and injected) in conjunction with a barrier method.
排除标准
- •Pregnant or breast feeding
- •Unstable or inadequately treated medical illness as judged by the investigator
- •Severe personality disorder
- •Serious suicidal risk as judged by the investigator or having a score ≥ 4 on Montgomery Asberg Depression Rating Scale (MADRS) item number 10 (suicidal thoughts) at screening or baseline
- •Known history of intolerance or hypersensitivity to pioglitazone
- •Treatment with pioglitazone in the 3 months prior to randomization
- •Dependence on alcohol or drugs (other than nicotine) in the 3 months prior to study entry
- •Currently taking insulin or rosiglitazone.
- •Diagnosed with dementia
- •Acute Mania as defined by a Young Mania Rating Scale (YMRS) score > 15
- •Diagnosed with heart failure
- •Transaminase elevation >2.5 times the upper limit of normal
- •Presence of renal impairment (eg. creatinine > 1.5)
- •History of bladder carcinoma
- •Fasting blood glucose >150 mg/dL and Hb A1c> 7%; participants meeting these criteria will be referred to an endocrinologist or their primary care physician for a diabetes evaluation and education.
- •Receiving acute series of electroconvulsive therapy
研究组 & 干预措施
Pioglitazone
干预措施: Pioglitazone (Drug)
Placebo
干预措施: Placebo (Drug)
结局指标
主要结局
Change in Inventory of Depressive Symptomatology-Clinician Rated (IDS-C30) Total Score
时间窗: Baseline and Week 8
Inventory of Depressive Symptomatology-Clinician Rated (IDS-C30) is designed to assess the severity of depressive symptoms. Total scores can range from 0 to 84 with higher scores indicating a higher severity of depressive symptoms
次要结局
未报告次要终点
研究者
Joseph Calabrese, MD
Director, Mood Disorders Program
University Hospitals Cleveland Medical Center