Characterization of Gastric Evoked Potentials
概览
- 阶段
- 不适用
- 干预措施
- Transcranial Magnetic Stimulation, TMS
- 疾病 / 适应症
- Healthy
- 发起方
- University of Pittsburgh
- 入组人数
- 155
- 试验地点
- 1
- 主要终点
- Change in GEP hotspot location
- 状态
- 招募中
- 最后更新
- 3个月前
概览
简要总结
This is an exploratory study that will determine and standardize how best to record gastric evoked potentials (GEPs) elicited by a non-invasive method of brain stimulation (Transcranial Magnetic Stimulation, TMS), by optimizing the TMS parameters and cortical sites necessary to evoke GEPs.
详细描述
The overall goal of this exploratory study is to determine the optimal conditions to elicit gastric evoked potentials (GEPs) with Transcranial Magnetic Stimulation (TMS). Aim 1: Determine the optimal stimulation parameters and the optimal location for eliciting GEPs in cortical motor areas. Aim 2: Determine whether various modes of repetitive TMS (rTMS) neuromodulation targeted to GEP hotspots shape gastric motor responses to a water load. The investigators will record some clinical, demographic, and autonomic data (i.e. EKG) in our enrolled subjects. Secondary analyses will use these variables as covariates to investigate any systematic impact on the measures from Aims 1 and 2.
研究者
David Levinthal
Associate Professor
University of Pittsburgh
入排标准
入选标准
- 未提供
排除标准
- •psychosis or altered cognitive status
- •history of head injury, metal in the skull, stroke, or a history of seizures, loss of consciousness or syncope
- •implantable devices, such as a pacemaker or nerve stimulator
- •current use of antiepileptic medications or current use of the following medications or substances which are known to lower the seizure threshold: Clozapine (Clozaril), Chlorpromazine (Thorazine), amphetamines or methamphetamine, Ecstasy, Ketamine, Angel Dust/PCP, cocaine, or 3 or more alcoholic drinks per day
- •pregnancy
- •BMI \> 30
- •history of bariatric surgery such as sleeve gastrectomy or Roux-en-Y gastric bypass
- •suffering from a neurodegenerative disorder.
研究组 & 干预措施
All participants
All participants
干预措施: Transcranial Magnetic Stimulation, TMS
结局指标
主要结局
Change in GEP hotspot location
时间窗: Multiple study sessions spanning up to 12 months
Stimulation location evoking the largest GEP response, relative to FDI hotspot location
Change in optimal stimulation parameters at GEP hotspot
时间窗: Multiple study sessions spanning up to 12 months
Stimulation pattern (single pulses or brief bursts) and strength relative to MT for FDI
次要结局
- Effect of satiety(Multiple study sessions spanning up to 12 months)
- Effect of neuromodulation(Multiple study sessions spanning up to 12 months)