The Acute Effect of Two Berry Extracts on Cognition and Mood in Adults Aged 40 to 60
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 1
- 主要终点
- Cognitive Measures - Memory- Assessed using a computerised cognitive batter.
研究概览
简要总结
The first study of my PhD showed that acute supplementation of berry extracts can modulate cognitive behaviour in healthy adults. There is a growing body of evidence supporting an improvement in memory and learning performance in animal models following the ingestion of flavonoid rich fruits (Shukitt-Hale et al 2008;Spencer 2008; Spencer et al., 2008). However, study 2, showed no effect on any aspects of memory in healthy young adults after supplementation of the berry extracts. It is hypothesised that the lack of behavioural effects on memory of the berry juice in study 2 was because of the cohort used. These healthy adult participants were already performing near to their peak (Salthouse et al., 2009), and unlike study one, participants were not mentally fatigued enough to reveal subtle cognitive benefits.
The aims of the study are to examine if acute supplementation of two berry extracts in an older population can augment memory, attention and executive function. Secondly, the time course of these behavioural effects will be measured by multiple cognitive assessments throughout the day after consumption of the extracts.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 40 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Non-smokers
- •Aged between 40 and 60 years
排除标准
- •History of neurological, vascular or psychiatric illness.
- •BMI greater than 35 kg/m2
- •Current diagnosis of depression and/or anxiety.
- •History or current diagnosis of drug/alcohol abuse.
- •Any heart disorder.
- •Hypertension
- •Any respiratory disorder.
- •Diabetes.
- •Food intolerances/sensitivities.
- •Phenylketonuria.
- •Use tobacco products or have ceased in the last 6 months.
- •Currently taking, or have taken in the last 2 weeks, any prescribed, illicit or herbal drugs and food supplements.
- •Any known active infections.
- •HIV antibody positive.
- •Currently have, have ever had, or may be at risk of hepatitis.
- •Have suffered from jaundice within the last year.
- •Have haemophilia or any similar clotting disorder.
- •History of head trauma
- •History of migraines
- •History of learning difficulties
- •Any Issues with giving blood samples.
研究组 & 干预措施
Control
Sugar matched control containing no phytochemicals
干预措施: Control (Dietary Supplement)
Juiced berry drink
Cold pressed berry drink standardised to contain 500mg of berry polyphenols
干预措施: Berry drink (Dietary Supplement)
Powdered berry drink
Berry drink made up from a powdered concentrate. each drink will be standardised to contain 500mg of polyphenols
干预措施: Powdered berry drink (Dietary Supplement)
结局指标
主要结局
Cognitive Measures - Memory- Assessed using a computerised cognitive batter.
时间窗: Change from baseline 60, 150, 240 and 360 minutes post dose
Cognitive Measures - Attention- Assessed using a computerised cognitive batter.
时间窗: Change from baseline 60, 150, 240 and 360 minutes post dose
Blood glucose
时间窗: Change from baseline at 60, 140, 180, 200, 230 and 350 minutes post dose
Blood lactate
时间窗: Change from baseline at 60, 140, 180, 200, 230 and 350 minutes post dose
Monoamine oxidase B inhibition
时间窗: Change from baseline at 350 minutes post dose
次要结局
未报告次要终点
研究者
Anthony Watson
Principal Investigator
Northumbria University