NCT04274790撤回不适用
Analysis of the Impact of 5-Fluorouracil on the Translational Control and Plasticity of Cancer Cells From Liver Metastases of Colon Cancer
适应症
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 1
- 主要终点
- 5-FU in ribosome
研究概览
简要总结
Analyze the dynamics of incorporation of 5-fluorouracil into cancer cell ribosomes from liver metastases of patient with metastatic colon cancer.
详细描述
This is a monocentric, prospective, non-interventional cohort study in adult patients with metastatic colon cancer with hepatics metastasis.
Tumour samples collected for this study include:
- A fragment of the previously operated primary tumor: FFIP block and/or archived frozen tumor if available.
- A fragment of the liver metastasis(s) performed as part of standard metastasis surgery, this fragment will include a tumor area and a healthy area within the margin of excision. These samples collected in a fresh state will be analyzed immediately.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient with metastatic colon cancer operated on and followed up at the Centre Leon Berard for liver metastasis.
- •Patient affiliated to social security
排除标准
- •Other pathologies that may interfere with biological evaluation, in particular known hepatic cirrhosis, whatever its origin, other liver overload diseases (hemochromatosis, Wilson's disease), but excluding steatosis (which can be chemo-induced).
结局指标
主要结局
5-FU in ribosome
时间窗: Up to 24 months
Rate of incorporation of 5-fluorouracil into ribosomes of tumor tissues and adjacent healthy tissues before surgery and after surgery.
次要结局
- Methylation profile of ribosomal RNAs(Up to 24 months)
- Specific molecular signature(Up to 24 months)
- Transcriptomic and proteomic profile(Up to 24 months)
研究者
研究点 (1)
Loading locations...
相似试验
已完成
2 期
Fluorouracil in Treating Patients With Recurrent or Metastatic Bladder CancerTransitional Cell Cancer of the Renal Pelvis and UreterUrethral CancerBladder CancerNCT00003175Medical Research Council45
已完成
2 期
S9700 Combination Chemotherapy in Treating Patients With Stage II or Stage III Pancreatic CancerPancreatic CancerNCT00003018SWOG Cancer Research Network54
已完成
3 期
Chemotherapy Plus Radiation Therapy in Treating Patients With Stage II or Stage III Anal CancerAnal CancerNCT00003596Radiation Therapy Oncology Group682
Unknown
1 期
Combination Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal CancerColorectal CancerNCT00003001Stony Brook University63
已完成
3 期
Combination Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal CancerColorectal CancerNCT00003287European Organisation for Research and Treatment of Cancer - EORTC554