the Application of Cardiopulmonary Exercise Testing in Assessment Outcome of Patients With Pulmonary Hypertension

Recruiting

• Conditions: Pulmonary Hypertension; Chronic Thromboembolic Pulmonary Hypertension; Pulmonary Arterial Hypertension Associated With Schistosomiasis (Disorder)
• Interventions: Device: balloon pulmonary angioplasty

• Registration Number: NCT02061787
• Lead Sponsor: Chinese Pulmonary Vascular Disease Research Group

Brief Summary

cardiopulmonary exercise test evaluate patients with pulmonary hypertension before and after medical or balloon pulmonary angioplasty treatment

Detailed Description

patients diagnosed with pulmonary hypertension, including pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension, will be evaluated by cardio pulmonary exercise test before and after medical or balloon pulmonary angioplasty treatment

Study Timeline

• Study Start: 2010-09
• Study First Submitted: 2014-02-11
• Study First Submitted QC: 2014-02-11
• Study First Posted: 2014-02-13
• Status Verified: 2022-07
• Last Update Submitted: 2022-07-29
• Last Update Posted: 2022-08-02
• Primary Completion: 2030-09-08
• Study Completion: 2030-09-08

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 4000

Inclusion Criteria

• pulmonary arterial hypertension;( WHO1)
• chronic thromboembolic pulmonary hypertension;
• pulmonary arterial hypertension due to other cause;

Exclusion Criteria

• massive hemoptysis;
• unable to accomplish cardiopulmonary exercise testing due to neuromuscular disorders;
• recent recurrent syncope;
• pulmonary hypertension due to hypoxia;
• pulmonary hypertension due to left heart diseases.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
cardiopulmonary exercise testing	balloon pulmonary angioplasty	patients diagnosed with pulmonary hypertension, including pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension, were evaluated by cardiopulmonary exercise testing before and after medical or balloon pulmonary angioplasty treatment

Primary Outcome Measures

Name	Time	Method
achievement of low risk	5 years	patients with chronic thromboembolic pulmonary hypertension achievement of low risk after balloon pulmonary angioplasty
mean pulmonary arterial pressure after treatment	5 years	the mean pulmonary arterial pressure of patients with chronic thromboembolic pulmonary hypertension after balloon pulmonary angioplasty treatment
all cause mortality	5 years	all cause mortality

Secondary Outcome Measures

Name	Time	Method
deterioration of WHO function	5 years	deterioration of WHO function

Trial Locations

Locations (1)

center of pulmonary vascular disease, Fuwai hospital; 🇨🇳 Beijing, China