Effect of Enhanced Recovery After Surgery (ERAS) on C-reactive and Visceral Proteins

Not Applicable

Completed

• Conditions: Gastric Cancer
• Interventions: Procedure: ERAS protocols; Procedure: conventional pathway group

• Registration Number: NCT02348229
• Lead Sponsor: The First Hospital of Jilin University

Brief Summary

The investigators designed a prospective randomized, controlled clinical trial then recruited 149 consecutive advanced gastric cancer patients. Further divided into a ERAS group (n=73) and a conventional pathway group (n=76). Surgical technique in both groups was same laparoscopic-assisted gastrectomy with D2 lymphadenectomy. Compared outcomes included clinical parameters and serum indicators.

Detailed Description

Enhanced recovery after surgery combined with laparoscopic-assisted gastrectomy was successfully carried out in this study. Recovery parameters such as the length of time to return to normal diet,mean hospital stay (d) were recorded.

Study Timeline

• Study Start: 2013-09
• Primary Completion: 2014-09
• Study Completion: 2014-10
• Status Verified: 2015-01
• Study First Submitted: 2015-01-17
• Study First Submitted QC: 2015-01-27
• Last Update Submitted: 2015-01-27
• Study First Posted: 2015-01-28
• Last Update Posted: 2015-01-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 149

Inclusion Criteria

1. Age 18-75 years old
2. Diagnosis confirmed by the endoscopic biopsy and total-body CT scan
3. No history of the chronic renal disease ,chronic liver disease, cardiopulmonary dysfunction, ASA score≦3
4. No neoadjuvant chemotherapy and radiotherapy
5. No digestive obstruction and distant metastasis

Exclusion Criteria

1. Conversion to open gastrectomy
2. A large amount of bleeding leading(>500ml)
3. Patients withdrew their consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
ERAS group	ERAS protocols	ERAS protocols
conventional pathway group	conventional pathway group	using conventional pathway

Primary Outcome Measures

Name	Time	Method
Compartition of postoperative hospital stay	up to 30 days after the operation

Secondary Outcome Measures

Name	Time	Method
Change from baseline in C-Reactive Protein( CRP) and visceral proteins level	baseline and 5 days	1day before and 1-5days after operation