Extension Study Of Tanezumab In Osteoarthritis
- Conditions
- Osteoarthritis
- Interventions
- Biological: tanezumab
- Registration Number
- NCT00809783
- Lead Sponsor
- Pfizer
- Brief Summary
Safety extension study of Phase 3 Osteoarthritis trials with Tanezumab
- Detailed Description
This study was terminated on 27 October 2010 following a US FDA clinical hold for tanezumab osteoarthritis clinical studies which halted dosing and enrollment of patients on 23 June 2010 for potential safety issues.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 2147
- Must have participated in previous (specific) Phase 3 trials of Tanezumab in osteoarthritis
- Willing to comply with scheduled visits and treatment plan Is medically fit to participate in the trial in the judgement of the Investigator
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Tanezumab 5 mg tanezumab Tanezumab 5 mg Tanezumab 10 mg tanezumab Tanezumab 10 mg Tanezumab 2.5 mg tanezumab Tanezumab 2.5 mg
- Primary Outcome Measures
Name Time Method Number of Participants With Treatment Emergent Adverse Events (AEs) And Serious Adverse Events (SAEs) A4091016: Baseline (Day 1) up to 112 days after last dose of study medication (up to Week 80) AE:any untoward medical occurrence in participant who received study medication without regard to possibility of causal relationship. SAE:an AE resulting in any of following outcomes or deemed significant for any other reason:death;initial or prolonged inpatient hospitalization;life-threatening experience(immediate risk of dying);persistent or significant disability/incapacity;congenital anomaly. Treatment-emergent are events between first dose of study medication and up to 112 days after last dose that were absent before treatment in this study or that worsened relative to pretreatment state. AEs included both SAEs and all non-SAEs.
Number of Participants With Clinically Significant Abnormal Electrocardiogram (ECG) Findings A4091016: Baseline (Day 1) up to Week 80 Following parameters were analyzed for ECG abnormality: PR interval, QRS interval, QT interval, QT interval corrected using the Fridericia's formula (QTcF), QT interval corrected using the Bazett's formula (QTcB), RR interval and VR interval. Number of participants with clinically significant abnormal ECG findings were judged by investigator and reported as adverse events were presented.
Number of Participants With Abnormal Laboratory Findings A4091016: Day 1 up to Week 80 Hemoglobin(Hgb),hematocrit,red blood cell(RBC):less than(\<)0.8\*lower limit of normal(LLN),MCV,MCH,MCHC\<0.9\*LLN or \>1.1\*ULN,platelet:\<0.5\*LLN or \>1.75\*upper limit of normal(ULN),white blood cell(WBC):\<0.6\*LLN or \>1.5\*ULN,lymphocyte,neutrophil,total neutrophil:\<0.8\*LLN or\>1.2\*ULN,basophil,eosinophil,monocyte:\>1.2\*ULN;total,direct bilirubin\>1.5\*ULN,aspartate aminotransferase,alanine aminotransferase,gamma-glutamyl transferase,LDH,alkaline phosphatase:\> 3.0\*ULN,total protein,albumin:\<0.8\*LLN or \>1.2\*ULN;blood urea nitrogen,creatinine:\>1.3\*ULN,uric acid\>1.2\*ULN;cholesterol,triglycerides\>1.3\*ULN;sodium \<0.95\*LLN or \>1.05\*ULN,potassium,chloride,calcium,magnesium,bicarbonate:\<0.9\*LLN or \>1.1\*ULN,phosphate\<0.8\*LLN or\>1.2\*ULN;glucose \<0.6\*LLN or \>1.5\*ULN,glycosylated Hgb \>1.3\*ULN,creatine kinase\>2.0\*ULN;urine(specific gravity \<1.003or\>1.030,pH \<4.5or\>8,glucose,ketone,protein,blood/Hgb,bilirubin,leukocyte esterase,crystals\>=1,RBC,WBC \>1.5\*ULN,epithelial cell\>=6,casts,hyaline cast\>1,bacteria\>20).
- Secondary Outcome Measures
Name Time Method Change From Parent Study Baseline in Neuropathy Impairment Score (NIS) at Week 4, 8, 16, 24, 32, 40, 48, 56, 64 and 72 Baseline of the parent study (A4091011, A4091014, A4091015, A4091018); A4091016: Week 4, 8, 16, 24, 32, 40, 48, 56, 64, 72 NIS constitutes sum of 37 standard items of neuromuscular examination used to assess muscle strength, reflexes and sensation. Each item is scored separately for left and right sides. Components of muscle weakness (24 items) scored on a scale: 0 (normal) to 4 (paralysis), with higher score=more weakness; components of reflexes and sensation (13 items) scored on a scale: 0= normal, 1= decreased or 2= absent. Total NIS score range 0 (no impairment) to 244 (maximum impairment), higher score = more impairment. Parent study baseline value calculated as average of pre-dose measurements of participants from study A4091011, A4091014, A4091015 and A4091018.
Number of Participants With Clinically Significant Abnormality in Vital Signs A4091016: Baseline (Day 1) up to Week 80 Following parameters were analyzed for examination of vital signs: body temperature, blood pressure, heart rate and respiratory rate. Number of participants with clinically significant abnormality in vital signs were judged by investigator and reported as adverse events were presented.
Change From Parent Study Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Average Score at Week 4, 8, 16, 24, 32, 40, 48, 56, 64, 72, 80, 88, 96 and 104 Baseline of the parent study (A4091011, A4091014, A4091015, A4091018); A4091016: Week 4, 8, 16, 24, 32, 40, 48,56, 64, 72, 80, 88, 96, 104 WOMAC: self-administered, disease-specific 24-item questionnaire which assesses clinically important, participant-relevant symptoms for pain (5 items), stiffness (2 items) and physical function (17 items) in participants with osteoarthritis of knee or hip. WOMAC average score is the mean of WOMAC pain, physical function and stiffness subscale scores and ranges from 0 (minimum difficulty) to 10 (maximum difficulty), where higher score indicates worse response. Parent study baseline value calculated as average of pre-dose measurements of the participants from study A4091011, A4091014, A4091015 and A4091018.
Number of Participants With Anti-drug Antibodies (ADA) for Tanezumab A4091016: Day 1, Week 16, 24, 40, 56, 72, 80 or Early Termination (ET: anytime till Week 80) Human serum anti-drug antibody (ADA) samples were analyzed for the presence or absence of anti-tanezumab antibodies by using the semi-quantitative enzyme-linked immunosorbent assay (ELISA). Same participant may have positive ADA result at more than 1 time point.
Change From Parent Study Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score at Week 4, 8, 16, 24, 32, 40, 48, 56, 64, 72, 80, 88, 96 and 104 Baseline of the parent study (A4091011, A4091014, A4091015, A4091018); A4091016: Week 4, 8, 16, 24, 32, 40, 48,56, 64, 72, 80, 88, 96, 104 The WOMAC pain subscale is a 5-item questionnaire used to assess the amount of pain experienced due to osteoarthritis in index knee or hip joint during past 48 hours. The WOMAC pain score is calculated as mean of the scores from 5 individual questions scored on a numerical rating scale (NRS) of 0 (minimum pain) to 10 (maximum pain), where higher scores indicate higher pain. Total score range for WOMAC pain subscale score is 0 (minimum pain) to 10 (maximum pain), where higher scores indicate higher pain. Parent study baseline value calculated as average of pre-dose measurements of the participants from study A4091011, A4091014, A4091015 and A4091018.
Change From Parent Study Baseline in Patient Global Assessment (PGA) of Osteoarthritis at Week 4, 8, 16, 24, 32, 40, 48, 56, 64, 72, 80, 88, 96 and 104 Baseline of the parent study (A4091011, A4091014, A4091015, A4091018); A4091016: Week 4, 8, 16, 24, 32, 40, 48,56, 64, 72, 80, 88, 96, 104 Participants answered: "Considering all the ways your osteoarthritis in your knee/hip affects you, how are you doing today?" Participants responded by using a 5-point scale where 1 = very good and 5 = very poor. Higher scores indicate worse condition. Parent study baseline value calculated as average of pre-dose measurements of the participants from study A4091011, A4091014, A4091015 and A4091018.
Change From Parent Study Baseline For Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Item: Pain When Going Up or Downstairs at Week 4, 8, 16, 24, 32, 40, 48, 56, 64, 72, 80, 88, 96 and 104 Baseline of the parent study (A4091011, A4091014, A4091015, A4091018); A4091016: Week 4, 8, 16, 24, 32, 40, 48,56, 64, 72, 80, 88, 96, 104 Participants answered: "How much pain have you had going up or down the stairs?" Participants responded by using a NRS of 0 to 10, where 0 = no pain and 10 = extreme pain. Higher score indicates more pain. Parent study baseline value calculated as average of pre-dose measurements of the participants from study A4091011, A4091014, A4091015 and A4091018.
Days Per Week of Concomitant Analgesic Medication Usage Week 1-4, 5-8, 9-16, 17-24, 25-32, 33-40, 41-48, 49-56, 57-64, 65-72, 73-80, 81-88, 89-96, 97-104, 105-112 FDA approved analgesics (over-the-counter or prescription) were permitted as concomitant medications to relieve the pain of osteoarthritis. These medications included opioids, topical analgesics, NSAIDs, capsaicin products, oral/injectable corticosteroids and viscosupplementation (hyaluronan) and were prescribed at the discretion of the investigator.
Number of Participants With Clinically Significant Changes From Baseline to Week 80 in Physical Examination Findings Baseline (Day 1) up to Week 80 Physical examination included examination of following sites in addition to general examination: abdomen, ears, extremities, eyes, head, heart, musculoskeletal, neck, nose, skin, throat and thyroid. Clinically significant changes were judged by investigator.
Change From Parent Study Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Physical Function Subscale Score at Week 4, 8, 16, 24, 32, 40, 48, 56, 64, 72, 80, 88, 96 and 104 Baseline of the parent study (A4091011, A4091014, A4091015, A4091018); A4091016: Week 4, 8, 16, 24, 32, 40, 48,56, 64, 72, 80, 88, 96, 104 The WOMAC physical function subscale is a 17-item questionnaire used to assess the degree of difficulty experienced due to osteoarthritis in index knee or hip joint during past 48 hours. The WOMAC physical function score is calculated as mean of the scores from 17 individual questions scored on a NRS of 0 (minimum difficulty) to 10 (maximum difficulty), where higher scores indicate worse function. Total score range for WOMAC physical function subscale score is 0 (minimum difficulty) to 10 (maximum difficulty), where higher scores indicate worse function. Parent study baseline value calculated as average of pre-dose measurements of the participants from study A4091011, A4091014, A4091015 and A4091018.
Change From Parent Study Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Stiffness Subscale at Week 4, 8, 16, 24, 32, 40, 48, 56, 64, 72, 80, 88, 96 and 104 Baseline of the parent study (A4091011, A4091014, A4091015, A4091018); A4091016: Week 4, 8, 16, 24, 32, 40, 48,56, 64, 72, 80, 88, 96, 104 WOMAC stiffness subscale: questionnaire used to assess amount of stiffness experienced due to osteoarthritis in index joint during past 48 hours. The WOMAC stiffness score is calculated as mean of scores from 2 individual questions scored on NRS of 0 (minimum stiffness) to 10 (maximum stiffness), higher scores indicate higher stiffness. Total score range for WOMAC stiffness subscale score =0 (minimum stiffness) to 10 (maximum stiffness), higher scores indicate higher stiffness. Stiffness is defined as sensation of decreased ease in movement of knee/hip. Parent study baseline value calculated as average of pre-dose measurements of the participants from study A4091011, A4091014, A4091015 and A4091018.
Percentage of Participants Who Used Concomitant Analgesic Medication Week 1-4, 5-8, 9-16, 17-24, 25-32, 33-40, 41-48, 49-56, 57-64, 65-72, 73-80, 81-88, 89-96, 97-104, 105-112 United States Food and Drug Administration (FDA) approved analgesics (over-the-counter or prescription) were permitted as concomitant medications to relieve the pain of osteoarthritis. These medications included opioids, topical analgesics, non-steroidal anti inflammatory drugs (NSAIDs), capsaicin products, oral/injectable corticosteroids and viscosupplementation (hyaluronan) and were prescribed as per investigator's discretion.
Percentage of Participants With Outcome Measures in Rheumatology - Osteoarthritis Research Society International (OMERACT-OARSI) Response A4091016: Week 4, 8, 16, 24, 32, 40, 48, 56, 64, 72, 80, 88, 96, 104 OMERACT-OARSI response:\>=50 percent(%) improvement from parent study baseline and absolute change from parent study baseline of \>=2 units at given week in WOMAC pain or physical function subscale or \>=20% improvement from parent study baseline and absolute change from parent study baseline of \>=1 unit at given week in at least 2 of following 3 items: 1)WOMAC pain subscale, 2)WOMAC physical function subscale, 3)PGA of osteoarthritis (score: 1-5, higher score=more affected).WOMAC pain, physical function subscales assess amount of pain/difficulty experienced (score:0-10, higher score=higher pain/difficulty).
Percentage of Participants With at Least 30%, 50%, 70% and 90% Reduction From Parent Study Baseline in WOMAC Pain Subscale Score Baseline of the parent study (A4091011, A4091014, A4091015, A4091018); A4091016: Week 4, 8, 16, 24, 32, 40, 48,56, 64, 72, 80, 88, 96, 104 The WOMAC pain subscale is a 5-item questionnaire used to assess the amount of pain experienced due to osteoarthritis in index knee or hip joint during past 48 hours. The WOMAC pain score is calculated as mean of the scores from 5 individual questions scored on a numerical rating scale (NRS) of 0 (minimum pain) to 10 (maximum pain), where higher scores indicate higher pain. Total score range for WOMAC pain subscale score is 0 (minimum pain) to 10 (maximum pain), where higher scores indicate higher pain. Parent study baseline value calculated as average of pre-dose measurements of the participants from study A4091011, A4091014, A4091015 and A4091018.
Number of Participants With Cumulative Reduction From Parent Study Baseline in Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score at Week 16, 24, 56 and 104 Baseline of the parent study (A4091011, A4091014, A4091015, A4091018); A4091016: Week 16, 24, 56, 104 The WOMAC pain subscale is a 5-item questionnaire used to assess the amount of pain experienced due to osteoarthritis in index knee or hip joint during past 48 hours. The WOMAC pain score is calculated as mean of the scores from 5 individual questions scored on a numerical rating scale (NRS) of 0 (minimum pain) to 10 (maximum pain), where higher scores indicate higher pain. Total score range for WOMAC pain subscale score is 0 (minimum pain) to 10 (maximum pain), where higher scores indicate higher pain. Parent study baseline value calculated as average of pre-dose measurements of the participants from study A4091011, A4091014, A4091015 and A4091018.
Percentage of Participants With Improvement of at Least 2 Points From Parent Study Baseline in Patient Global Assessment (PGA) of Osteoarthritis Baseline of the parent study (A4091011, A4091014, A4091015, A4091018); A4091016: Week 4, 8, 16, 24, 32, 40, 48,56, 64, 72, 80, 88, 96, 104 Participants answered: "Considering all the ways your osteoarthritis in your knee/hip affects you, how are you doing today?" Participants responded by using a 5-point scale where 1 = very good and 5 = very poor. Higher scores indicated worse pain. Parent study baseline value calculated as average of pre-dose measurements of the participants from study A4091011, A4091014, A4091015 and A4091018.
Change From Parent Study Baseline For Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Item: Pain When Walking on a Flat Surface at Week 4, 8, 16, 24, 32, 40, 48, 56, 64, 72, 80, 88, 96 and 104 Baseline of the parent study (A4091011, A4091014, A4091015, A4091018); A4091016: Week 4, 8, 16, 24, 32, 40, 48,56, 64, 72, 80, 88, 96, 104 Participants answered: "How much pain have you had when walking on a flat surface?" Participants responded by using a NRS of 0 to 10, where 0 = no pain and 10 = extreme pain. Higher score indicates more pain. Parent study baseline value calculated as average of pre-dose measurements of the participants from study A4091011, A4091014, A4091015 and A4091018.
Trial Locations
- Locations (218)
Laureate Clinical Research Group
🇺🇸Atlanta, Georgia, United States
Arthritis and Rheumatology of Georgia
🇺🇸Atlanta, Georgia, United States
Rehabilitation Institute of Chicago
🇺🇸Chicago, Illinois, United States
Innovative Research of West Florida, Inc.
🇺🇸Clearwater, Florida, United States
In Vivo Clinical Research, Inc
🇺🇸Doral, Florida, United States
Edinger Medical Group Clinical Research
🇺🇸Fountain Valley, California, United States
Stamford Therapeutics Consortium
🇺🇸Stamford, Connecticut, United States
River Birch Research Alliance, LLC
🇺🇸Blue Ridge, Georgia, United States
Clinical Research Center of Connecticut
🇺🇸Danbury, Connecticut, United States
Valley Research
🇺🇸Fresno, California, United States
High Desert Medical Group Research for Life
🇺🇸Lancaster, California, United States
Probe Clinical Research, Corp.
🇺🇸Santa Ana, California, United States
Trinity Clinical Trials
🇺🇸Santa Ana, California, United States
HeartCare (Private Practice)
🇺🇸Bradenton, Florida, United States
Norwalk Medical Group
🇺🇸Norwalk, Connecticut, United States
Palm Beach Research Center
🇺🇸West Palm Beach, Florida, United States
Jefrey D. Lieberman, MD
🇺🇸Decatur, Georgia, United States
Asif Cochinwala, MD, PA
🇺🇸Houston, Texas, United States
Foundation for Southwest Orthopedic Research
🇺🇸Houston, Texas, United States
The Neurology Center
🇺🇸Houston, Texas, United States
Pharmax Research Clinic, Inc
🇺🇸Miami, Florida, United States
Kendall South Medical Center, Inc.
🇺🇸Miami, Florida, United States
Independent Clinical Researchers
🇺🇸Las Vegas, Nevada, United States
Wolfson Medical Center
🇺🇸Las Vegas, Nevada, United States
Clinical Research Consortium
🇺🇸Las Vegas, Nevada, United States
Arizona Research Center
🇺🇸Phoenix, Arizona, United States
Delaware Arthritis
🇺🇸Lewes, Delaware, United States
Sonora Clinical Research, LLC.
🇺🇸Boise, Idaho, United States
Odyssey Research
🇺🇸Fargo, North Dakota, United States
University Parks Hematology/Oncology
🇺🇸Englewood, Colorado, United States
American Clinical Research, LLC
🇺🇸Englewood, Colorado, United States
Orthopaedic Physicians Of Colorado, P.C.
🇺🇸Englewood, Colorado, United States
Professional Research Network of Kansas, LLC
🇺🇸Wichita, Kansas, United States
Peak Anesthesia and Pain Management
🇺🇸Centennial, Colorado, United States
Advanced Orthopedic and Sports Medicine
🇺🇸Parker, Colorado, United States
Plains Medical Clinic, LLC
🇺🇸Fargo, North Dakota, United States
Clinical Research Advantage, Inc.
🇺🇸Phoenix, Arizona, United States
Clincial Research Advantage, Inc/Central Phoenix Medical Clinic, LLC
🇺🇸Phoenix, Arizona, United States
Arizona Arthritis & Rheumatology Associates, P.C.
🇺🇸Phoenix, Arizona, United States
Health Research Institute
🇺🇸Oklahoma City, Oklahoma, United States
Greystone Medical Center
🇺🇸Birmingham, Alabama, United States
Denver Internal Medicine Group
🇺🇸Denver, Colorado, United States
Mountain View Clinical Research, Inc.
🇺🇸Denver, Colorado, United States
Quality Clinical Research, Inc.
🇺🇸Omaha, Nebraska, United States
Colorado Orthopedic Consultants, PC
🇺🇸Aurora, Colorado, United States
Tampa Medical Group, PA
🇺🇸Tampa, Florida, United States
Quality of Life Medical and Research Center
🇺🇸Tucson, Arizona, United States
Pinncale Research Group, LLC
🇺🇸Anniston, Alabama, United States
Anniston Medical Clinic, PC
🇺🇸Anniston, Alabama, United States
Pinnacle Research Group, LLC
🇺🇸Anniston, Alabama, United States
Saadat Ansari, MD Office
🇺🇸Huntsville, Alabama, United States
Coastal Clinical Research, Inc.
🇺🇸Mobile, Alabama, United States
Horizon Research Group
🇺🇸Mobile, Alabama, United States
Novara Clinical Research
🇺🇸Mesa, Arizona, United States
Arizona Arthritis & Rheumatology Research, PLLC
🇺🇸Paradise Valley, Arizona, United States
Pivotal Research Center
🇺🇸Peoria, Arizona, United States
Quality of Life Medical & Research Center, LLC
🇺🇸Tucson, Arizona, United States
University of Arizona
🇺🇸Tucson, Arizona, United States
Tucson Orthopaedic Institute
🇺🇸Tucson, Arizona, United States
St. Joseph's Mercy Clinic
🇺🇸Hot Springs, Arkansas, United States
Providence Clinical Research
🇺🇸Burbank, California, United States
Osteoporosis Medical Center
🇺🇸Beverly Hills, California, United States
eStudySite
🇺🇸Chula Vista, California, United States
Colorado Hematology - Oncology
🇺🇸Englewood, California, United States
Lakewood Orthopedic Medical & Surgical Group
🇺🇸Lakewood, California, United States
Talbert Medical Group
🇺🇸Huntington Beach, California, United States
Arthritis Medical Clinic of North County, Inc.
🇺🇸Escondido, California, United States
Premiere Clinical Research, LLC
🇺🇸Long Beach, California, United States
Samaritan Center for Medical Research
🇺🇸Los Gatos, California, United States
Office of Lawrence P McAdam, MD
🇺🇸Thousand Oaks, California, United States
Del Carmen Medical Center
🇺🇸Reseda, California, United States
Westlake Medical Research
🇺🇸Westlake Village, California, United States
Tampa Bay Medical Research, Inc.
🇺🇸Clearwater, Florida, United States
Clinical Research of South Florida
🇺🇸Coral Gables, Florida, United States
Arthritis Associates of South Florida
🇺🇸Delray Beach, Florida, United States
Avail Clinical Research, LLC
🇺🇸DeLand, Florida, United States
Delray Research Associates
🇺🇸Delray Beach, Florida, United States
S & W Clinical Research
🇺🇸Fort Lauderdale, Florida, United States
Westside Center for Clinical Research
🇺🇸Jacksonville, Florida, United States
Adult Medicine Specialists
🇺🇸Longwood, Florida, United States
Genesis Research International
🇺🇸Longwood, Florida, United States
Centre for Rheumatology, Immunology and Arthritis
🇺🇸Fort Lauderdale, Florida, United States
Sunshine Research Center
🇺🇸Opa-locka, Florida, United States
University Clinical Research Incorporated
🇺🇸Pembroke Pines, Florida, United States
Advent Clinical Research Centers, Inc.
🇺🇸Pinellas Park, Florida, United States
The Arthritis Center
🇺🇸Springfield, Illinois, United States
HeartCare Research
🇺🇸Sarasota, Florida, United States
Progressive Medical Research
🇺🇸Port Orange, Florida, United States
Dale G. Bramlet, MD, P.L.
🇺🇸Saint Petersburg, Florida, United States
West Broward Rheumatology Associates, Inc.
🇺🇸Tamarac, Florida, United States
Early Family Practice Center
🇺🇸Fort Valley, Georgia, United States
Northeast Georgia Diagnostic Clinic, LLC
🇺🇸Gainesville, Georgia, United States
Marietta Rheumatology Associates
🇺🇸Marietta, Georgia, United States
North Georgia Clinical Research
🇺🇸Woodstock, Georgia, United States
North Georgia Internal Medicine
🇺🇸Woodstock, Georgia, United States
Millennium Pain Center
🇺🇸Bloomington, Illinois, United States
Illinois Bone and Joint Institute, LLC
🇺🇸Morton Grove, Illinois, United States
Koch Family Medicine
🇺🇸Morton, Illinois, United States
MediSphere Medical Research Center, LLC
🇺🇸Evansville, Indiana, United States
American Health Network
🇺🇸Fishers, Indiana, United States
Northwest Indiana Center for Clinical Research
🇺🇸Valparaiso, Indiana, United States
Pasadena Pharmacy
🇺🇸Lexington, Kentucky, United States
McFarland Clinic, PC
🇺🇸Ames, Iowa, United States
Arthritis Center of Lexington
🇺🇸Lexington, Kentucky, United States
Integrated Clinical Trial Services, Inc.
🇺🇸West Des Moines, Iowa, United States
The Pain Treatment Center of the Bluegrass
🇺🇸Lexington, Kentucky, United States
Bluegrass Community Research, Inc
🇺🇸Lexington, Kentucky, United States
Stanocola Medical Center
🇺🇸Baton Rouge, Louisiana, United States
Bone and Joint Clinic of Baton Rouge
🇺🇸Baton Rouge, Louisiana, United States
Maine Research Associates
🇺🇸Auburn, Maine, United States
Mid-Atlantic Medical Research Centers
🇺🇸Hollywood, Maryland, United States
Arthritis and Diabetes Clinic
🇺🇸Monroe, Louisiana, United States
Miray Medical Center
🇺🇸Brockton, Massachusetts, United States
The Center for Rheumatology and Bone Research
🇺🇸Wheaton, Maryland, United States
Mansfield Health Center
🇺🇸Mansfield, Massachusetts, United States
Beacon Clinical Research, LLC
🇺🇸Brockton, Massachusetts, United States
Arthritis Associates Inc.
🇺🇸Peabody, Massachusetts, United States
Great Lakes Research Group, Incorporated
🇺🇸Bay City, Michigan, United States
KMED Research
🇺🇸Saint Clair Shores, Michigan, United States
MAPS Applied Research Center Inc.
🇺🇸Edina, Minnesota, United States
Medical Advanced Pain Specialists
🇺🇸Edina, Minnesota, United States
Planters Clinic
🇺🇸Port Gibson, Mississippi, United States
Medex Healthcare Research
🇺🇸New York, New York, United States
Mercy Health Research
🇺🇸Saint Louis, Missouri, United States
St. John's Clinic - Neurology
🇺🇸Springfield, Missouri, United States
St. John's Medical Research Institute, Inc.
🇺🇸Springfield, Missouri, United States
Diagnostic Center of Medicine
🇺🇸Henderson, Nevada, United States
Midwest Minor Medical
🇺🇸Omaha, Nebraska, United States
Comprehensive Clinical Research
🇺🇸Berlin, New Jersey, United States
Office of Dr. Danka Michaels, MD
🇺🇸Las Vegas, Nevada, United States
Mirkil Medical
🇺🇸Las Vegas, Nevada, United States
SPRI Bronx LLC
🇺🇸Bronx, New York, United States
G. Timothy Kelly, MD
🇺🇸Las Vegas, Nevada, United States
Albuquerque Clinical Trials
🇺🇸Albuquerque, New Mexico, United States
New Mexico Clinical Research & Osteoporosis Center, Incorporated
🇺🇸Albuquerque, New Mexico, United States
Arthritis and Osteoporosis Medical Associates
🇺🇸Brooklyn, New York, United States
Prem C. Chatpar, MD, LLC
🇺🇸Plainview, New York, United States
AAIR Research Center
🇺🇸Rochester, New York, United States
Carolina Bone & Joint, PA
🇺🇸Charlotte, North Carolina, United States
The Medical Research Network, LLC
🇺🇸New York, New York, United States
Pharmquest
🇺🇸Greensboro, North Carolina, United States
Arthritis and Osteoporosis Consultants of the Carolinas
🇺🇸Charlotte, North Carolina, United States
Office of Dr. Andrew Porges
🇺🇸Roslyn, New York, United States
Consultants for Clinical Research Incorporated
🇺🇸Cincinnati, Ohio, United States
Ohio GI and Liver Institute
🇺🇸Cincinnati, Ohio, United States
Hilltop Medical Research Center
🇺🇸Cincinnati, Ohio, United States
Columbus Clinical Research, Inc.
🇺🇸Columbus, Ohio, United States
Paramount Medical Research and Consulting, LLC
🇺🇸Middleburg Heights, Ohio, United States
PHP Center for Clinical Research
🇺🇸Dayton, Ohio, United States
Physicians' Research, Inc
🇺🇸Zanesville, Ohio, United States
Orthopaedic & Sports Medicine Consultants
🇺🇸Middletown, Ohio, United States
Pharmacotherapy Research Associates,Inc
🇺🇸Zanesville, Ohio, United States
Primecare of Southeastern Ohio, Inc
🇺🇸Zanesville, Ohio, United States
Signal Point Clinical Research Center
🇺🇸Middletown, Ohio, United States
East Penn Rheumatology Associates, PC
🇺🇸Bethlehem, Pennsylvania, United States
Cor Clinical Research, LLC
🇺🇸Oklahoma City, Oklahoma, United States
Altoona Center for Clinical Research
🇺🇸Duncansville, Pennsylvania, United States
Clinical Research Center of Reading, LLP
🇺🇸Wyomissing, Pennsylvania, United States
Brandywine Clinical Research
🇺🇸Downingtown, Pennsylvania, United States
The Family Healthcare Center, PA
🇺🇸Clinton, South Carolina, United States
Southern Orthopaedic Sports Medicine
🇺🇸Columbia, South Carolina, United States
Coastal Carolina Research Center
🇺🇸Mount Pleasant, South Carolina, United States
The Carolina Center for Rheumatology and Arthritis Care, PA
🇺🇸Rock Hill, South Carolina, United States
State of Franklin Healthcare Associates, PLLC
🇺🇸Johnson City, Tennessee, United States
Health Concepts
🇺🇸Rapid City, South Dakota, United States
Holston Medical Group
🇺🇸Kingsport, Tennessee, United States
Crown Imaging
🇺🇸Dallas, Texas, United States
North Texas Joint Care, PA
🇺🇸Dallas, Texas, United States
Metroplex Clinical Research Center
🇺🇸Dallas, Texas, United States
One Step Diagnostic
🇺🇸Houston, Texas, United States
Southwest Orthopedic Group
🇺🇸Houston, Texas, United States
O. David Taunton, Jr, MD
🇺🇸Grapevine, Texas, United States
Pioneer Research Solutions, Inc.
🇺🇸Houston, Texas, United States
Texas Arthritis Research Center, PA
🇺🇸San Antonio, Texas, United States
Diagnostics Research Group
🇺🇸San Antonio, Texas, United States
Gill Orthopedic Center
🇺🇸Lubbock, Texas, United States
Radiant Research San Antonio Northeast
🇺🇸San Antonio, Texas, United States
Robert R. King, M.D.
🇺🇸Lubbock, Texas, United States
Clinical Investigations of Texas, LLC
🇺🇸Plano, Texas, United States
Spring Family Practice Associates PA
🇺🇸Spring, Texas, United States
Sugar Land Med-Ped, P.A.
🇺🇸Sugar Land, Texas, United States
Aspen Clinical Research
🇺🇸Orem, Utah, United States
Grayline Clinical Drug Trials
🇺🇸Wichita Falls, Texas, United States
AZ Clinical Research
🇺🇸Sugar Land, Texas, United States
Spring Clinical Research
🇺🇸Sugar Land, Texas, United States
J. Lewis Research, Incorporated/Foothill Family Clinic South
🇺🇸Salt Lake City, Utah, United States
Foothill Family Clinic
🇺🇸Salt Lake City, Utah, United States
IntegraTrials, LLC
🇺🇸Arlington, Virginia, United States
Commonwealth Orthopaedics and Rehabilitation, PC
🇺🇸Arlington, Virginia, United States
Virginia Hospital Center
🇺🇸Arlington, Virginia, United States
Charlottesville Medical Research
🇺🇸Charlottesville, Virginia, United States
National Clinical Research - Norfolk, Inc.
🇺🇸Norfolk, Virginia, United States
Office of Doris M. Rice, MD, FACR
🇺🇸Portsmouth, Virginia, United States
HhypotheTest, LLC
🇺🇸Roanoke, Virginia, United States
Empirical Clinical Trials
🇺🇸Selah, Washington, United States
Arthritis Northwest
🇺🇸Spokane, Washington, United States
Clinical Trials Northwest
🇺🇸Yakima, Washington, United States
Masters of Clinical Research, Inc.
🇺🇸Augusta, Georgia, United States
Memorial Medical Group Clinical Research Institute
🇺🇸South Bend, Indiana, United States
Javed Rheumatology Associates, Inc.
🇺🇸Newark, Delaware, United States
Gulf Coast Research, LLC
🇺🇸Baton Rouge, Louisiana, United States
The Baton Rouge Clinic
🇺🇸Baton Rouge, Louisiana, United States
Clinical Pharmacology Study Group
🇺🇸Worcester, Massachusetts, United States
Clinical Research Advantage, Inc./Mesa Family Medical Center, PC
🇺🇸Mesa, Arizona, United States
Clinical Research Advantage, Inc./Central Arizona Medical Associates, PC
🇺🇸Mesa, Arizona, United States
Paradigm Clinical, Inc.
🇺🇸Tucson, Arizona, United States
L-Marc Research Center
🇺🇸Louisville, Kentucky, United States
Low Country Rheumatology, PA
🇺🇸Charleston, South Carolina, United States
Compass Research, LLC
🇺🇸Orlando, Florida, United States
Rheumatology Associates of Central Florida
🇺🇸Orlando, Florida, United States
David H. Neustadt, MD
🇺🇸Louisville, Kentucky, United States
Ann Arbor Clinical Research
🇺🇸Ann Arbor, Michigan, United States
PMG Research of Winston-Salem
🇺🇸Winston-Salem, North Carolina, United States
Capitol Medical Clinic
🇺🇸Austin, Texas, United States
Walter F. Chase, MD, PA
🇺🇸Austin, Texas, United States
Tekton Research, Inc.
🇺🇸Austin, Texas, United States
Arthritis Treatment Center
🇺🇸Frederick, Maryland, United States
Radiant Research
🇺🇸Dallas, Texas, United States