Investigation of the mechanism and enzyme responsible for the conversion of cotinine back to nicotine using human plasma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 168
- 试验地点
- 1
- 主要终点
- The study will estimate and compare the plasma levels of SOD,CAT,GPx in smokers and non somokers
研究概览
简要总结
Our early clinical study (ICMR Clinical Trial Registry India Registration No: CTRI/2022/12/048600). with smoker’s plasma samples was conclusively prove that the nicotine convert cotinine can be convert back to nicotine using Antioxidant (Ascorbic acid). The study result was the first time in the literature and the exact reason for the conversion of cotinine back to nicotine is uncertain. Interestingly, the conversion of cotinine back to nicotine was not happening in plasma without ascorbic acid or in water, therefore it indicates that some Antioxidant enzyme in plasma will involve and cotinine back to nicotine. Therefore, in this study attempt to explore the enzyme response for the conversion of cotinine back to nicotine in human plasma.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Chronic smoker
- •patients above 18 years old
- •consumer of other tobacco products such as chewed products, electronic cigarette, etc.
排除标准
- •Patients with no smoking effect
- •Pregnant women
- •Patients taken alcohol within 24 hours.
结局指标
主要结局
The study will estimate and compare the plasma levels of SOD,CAT,GPx in smokers and non somokers
时间窗: 6 months
次要结局
- mechanism of the conversion of cotinine back to nicotine in presence of ascrobic acid(6 months)
研究者
Dr Murugesan Arumugam
Sri Ramachandra Institute of Higher Education and Research, Chennai-600116