Effects of Auditory Brain Stimulation by "Pink Noise" on Memory Capacities in Alzheimer's Disease: Proof of Concept Study
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Alzheimer's Disease (AD)
- Sponsor
- University Hospital, Tours
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- difference between morning and eve of the number of reminders found between the "ON-stimulation" condition and the "OFF-stimulation" condition, on the memory task of word matching.
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
Alzheimer's disease (AD) is a neurodegenerative disorder affecting almost 6% of the world's population over the age of 65. This disease, in its most typical sporadic form, is characterized by an episodic memory impairment linked to a deficit in consolidation. Many studies indicate that sleep promotes this consolidation stage during the deep slow sleep stage by facilitating the transfer of information between the hippocampus and the neocortex.
A method of acoustic brain stimulation at night by pink noises has been recently developed and has shown its effectiveness in strengthening memory consolidation in healthy volunteers. Actually, there is no study observing the effect of this new stimulation method on populations with neurodegenerative pathologies, in particular in AD for which this technique could potentially become a therapeutic option.
The hypothesis is that of a strengthening of the memory consolidation capacities in subjects with AD as has been shown in healthy subjects.
Detailed Description
Alzheimer's disease (AD) is a neurodegenerative disorder affecting almost 6% of the world's population over the age of 65. This disease, in its most typical sporadic form, is characterized by an episodic memory impairment linked to a deficit in consolidation. Many studies indicate that sleep promotes this consolidation stage during the deep slow sleep stage by facilitating the transfer of information between the hippocampus and the neocortex. A method of acoustic brain stimulation at night by pink noises has been recently developed and has shown its effectiveness in strengthening memory consolidation in healthy volunteers. Actually, there is no study observing the effect of this new stimulation method on populations with neurodegenerative pathologies, in particular in AD for which this technique could potentially become a therapeutic option. The hypothesis is that of a strengthening of the memory consolidation capacities in subjects with AD as has been shown in healthy subjects.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
difference between morning and eve of the number of reminders found between the "ON-stimulation" condition and the "OFF-stimulation" condition, on the memory task of word matching.
Time Frame: Day 15
gross variation of the difference between morning and eve of the number of reminders found between the "ON-stimulation" condition and the "OFF-stimulation" condition, on the memory task of word matching.
Secondary Outcomes
- amplitude of slow waves in deep slow sleep between the "ON-stimulation" condition and the "OFF-stimulation" condition(Day 15)
- The memory complaint for Mc Nair's Questionnaire(Day 15)
- Psychoaffective aspects (Depression) for MADRS (Montgomery Asberg Depression Rating Scale)(Day 15)
- Psychoaffective aspects (Anxiety) for HAMA (Hamilton Anxiety)(Day 15)
- Number of reminders found between the "ON-stimulation" condition and the "OFF-stimulation" condition, on the ecological memory task.(Day 15)
- Quality of sleep for Pittsburgh Index (PSQI)(Day 15)