Probiotic Intervention and Its Influence on Serum Leucine-Rich Alpha-2 Glycoprotein 1 Levels in Acne Vulgaris Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Serum Leucine-Rich Alpha-2 Glycoprotein 1 Level
研究概览
简要总结
This study aimed to assess the serum level of Leucine-rich alpha-2 glycoprotein 1 (LRG1) in Acne vulgaris (AV) individuals and evaluate the effect of probiotic therapy on these serum levels.
详细描述
Acne vulgaris (AV) is a common inflammatory disorder of the pilosebaceous units, characterized by the presence of inflammatory, non-inflammatory, or a combination of both types of lesions.
Recent attention has turned toward biomarkers that reflect the inflammatory activity in acne and might act as indicators of disease severity, treatment response, or prognostic risk. One such candidate is Leucine-rich alpha-2 glycoprotein 1 (LRG1).
Probiotics are live microorganisms that, when administered in sufficient quantities, can modulate the composition of the gut microbiota, helping reduce microbial dysbiosis, regulate the immune response, and decrease inflammatory mediators, thereby reducing systemic inflammatory burden, which is called the gut-skin-axis relationship.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age ≥18 years.
- •Both sexes.
- •Had not used systemic or topical acne therapy for at least two months or two weeks before the research, respectively.
- •Participants with clinically diagnosed mild to moderate acne vulgaris (AV) based on the Global Acne Grading System (GAGS)
排除标准
- •Pregnancy.
- •Lactation.
- •History of hypersensitivity to probiotic components.
- •Presence of infections.
- •Autoimmune or malignant diseases.
- •Receiving any systemic therapy likely to affect the microbiome or inflammatory biomarkers.
结局指标
主要结局
Serum Leucine-Rich Alpha-2 Glycoprotein 1 Level
时间窗: 12 weeks after the therapy
Serum Leucine-Rich Alpha-2 Glycoprotein 1 Level was assessed.
次要结局
- Acne severity(12 weeks after the therapy)
- Patient satisfaction(12 weeks after the therapy)
研究者
Zeinab Ali Awad Menesy
MBBCH of Dermatology, Venereology and Andrology, Benha University, Benha, Egypt.
Benha University