Evaluation of The Potential Therapeutic Effects of Licorice and Boswellia Serrata Gum in Egyptian Patients With COVID-19 as a Complementary Medicine
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Increased number of people recovering from COVID-19
研究概览
简要总结
Boswellia Serrata gum and Licorice extract are two nutritional agents that have pharmacological actions that could support the medical intervention for COVID-19. They have broad antiviral activity, anti-inflammatory, anti-lung injury, antibacterial activity, antithrombic formation, and immunomodulatory activity.
The study will be conducted after January 18, 2017
详细描述
Since last December 2019, a syndrome of severe pneumonia associated with the coronavirus disease 2019 (COVID-19) emerged in Wuhan, Hubei Province, China. It is highly contagious and rapidly spread to many other parts of China and almost all countries all over the world, representing one of the most aggressive pandemics ever reported.
To date, April 21, 2020, More than 2.5 million persons were infected and more than 171.000 deaths with more fears all over the world from the multiplication of the total deaths. This huge no. of patients made a horrible pressure on health care facilities in all countries and lots of patients were not able to receive the appropriate medical care in hospitals WHO declared that to date, there is no specific medicine recommended to prevent or treat the novel coronavirus. However, in China, historically, when the outbreak started, Traditional Chinese medicine (TCM) approaches including oral administration of preventive herbal formulae, wearing TCM sachets, indoor herbal medicine fumigation, etc. were recommended for prevention and treatment.
For example, in 2003, TCM approaches were used to prevent and treat severe acute respiratory syndrome (SARS) which was the most serious infectious disease outbreak in China prior to the COVID-19. In 2009, during the pandemic of H1N1 influenza around the world, the National Administration of Traditional Chinese Medicine of China issued a CM prevention program, which included 4 Chinese herbal medicine (CHM) formulae for adults of different CM body constitutions and one for children. The current outbreak of COVID-19 resulted in many provinces in China issuing CM prevention and control programs, among which the prevention programs are mainly oral CHM formulae.
Glycyrrhizin, a component of many formulae, has reported having anti-inflammatory, antiviral and antioxidant properties. Also, Boswellia Gum Resin has many active components that have many medicinal properties such as antimicrobial, antioxidant, antifungal, anti-inflammatory, immuno-modulatory.
Efficacy:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 12 Years 至 65 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Symptomatic and laboratory-confirmed diagnosis of COVID-
- •RT-PCR indicates positive for novel coronavirus RNA
- •Viral specific IgM and IgG are detectable in serum
- •Viral specific IgG is detectable from negative to positive, OR
- •Viral specific IgG antibody reaches a titration of at least 4-fold higher in the recovery stage than in the acute stage
排除标准
- •Patients who are not fulfilling the diagnostic criteria for COVOID-
- •Pregnant women.
- •Critically ill patients who are mechanically ventilated since admission.
- •Hypertensive patients.
- •Congestive heart failure patients
结局指标
主要结局
Increased number of people recovering from COVID-19
时间窗: 14 days
Conversion of RT-PCR indicates positive for novel coronavirus RNA to negative
次要结局
- Decrease number of patients that require respiratory support ,(14 days)
- Decrease duration of hospital stay(7 days)
研究者
Adel Gomaa
Professor of medical pharmacology
Egyptian Biomedical Research Network