Krill Oil Study Compared to Fish Oil

Not Applicable

Completed

• Conditions: Healthy Volunteers
• Interventions: Dietary Supplement: Krill oil; Dietary Supplement: Fish Oil

• Registration Number: NCT01323036
• Lead Sponsor: University of Manitoba

Brief Summary

The main purpose of the study is to evaluate the absorption of omega-3 fatty acids into the blood following consumption of krill oil compared with fish oil and placebo.

Detailed Description

The main purpose of the study is to evaluate the absorption of omega-3 fatty acids into the blood following consumption of krill oil compared with fish oil and placebo. An additional purpose is to evaluate the lipid-lowering efficacy and safety of consumption of Krill Oil and Fish Oil to a placebo product. It has been shown that the ingestion of Krill Oil leads to better absorption of omega-3 fatty acids compared to ingestion of Fish Oil. It was also shown that consumption of krill oil and fish oil result in a favorable modification of lipid profiles. Therefore, it is anticipated that consumption of these krill oil and fish oil will improve lipid profile, as well as other health-related markers and will be safe and well tolerated.

Study Timeline

• Study First Submitted: 2011-03-23
• Study First Submitted QC: 2011-03-24
• Study First Posted: 2011-03-25
• Study Start: 2011-05
• Primary Completion: 2011-12
• Status Verified: 2012-11
• Study Completion: 2012-11
• Last Update Submitted: 2012-11-21
• Last Update Posted: 2012-11-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

• healthy men and premenopausal not pregnant or nursing women between 18 and 49 years old.

Exclusion Criteria

• smokers
• rheumatoid arthritis
• chronic illness
• cardiovascular problems
• dyslipidemia
• liver and kidney disease
• diabetes
• endocrine or metabolic disease
• inflammatory bowel disease
• pancreatitis
• gallbladder or biliary disease
• neurological/psychological disease
• bleeding disorders
• experienced platelet abnormalities
• gastrointestinal disorders that could interfere with fat absorption
• hypertension
• history of cancer
• an intention to lose weight
• use of anticoagulant
• serum triglycerides (TG) >200 mg/dL, and/or total cholesterol (TC) >240 mg/dL, and/or LDL-cholesterol (LDL-C) >160 mg/dL
• hypertension or lipid lowering medications
• consumption of more than one alcoholic drinks/day
• Consumption of more than one fish or seafood serving
• one month prior to the start of the study
• omega-6 fatty acids in the past 6 months
• planned to consume seafood products or fish or to use any omega-3 or omega-6 fatty acids nutritional supplements at anytime in the duration of the study
• planned to to become pregnant during the study period
• BMI>28
• allergies to fish seafood or corn

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Krill Oil	Krill oil	-
Fish Oil	Fish Oil	-

Primary Outcome Measures

Name	Time	Method
Bioavailability	1 month

Trial Locations

Locations (1)

Richardson Centre for Functional Foods and Nutraceuticals; 🇨🇦 Winnipeg, Manitoba, Canada