Clinical and immunological profile of systemic lupus erythematosus with special emphasis on neutrophil lymphocyte ratio and mean platelet volume as markers of disease activity.

SLE is a systemic autoimmune disease of unknown etiology with varied clinical and laboratory characteristics, it can potentially cause substantial physical and functional disability, ranging from a rash to renal failure or even death. There is a lack of SLE registries from INDIA, which poses as a major barrier to understand patient and disease characteristics. To predict the SLE flare, we currently have a 24 parameter SLEDAI score, but no single lab test exists to recognize the flare and increase in SLE disease activity. Several studies suggest that people with active SLE have neutrophilia and lymphopenia***.*** The presence of Anti lymphocyte antibody is important in the mechanism of lymphopenia in SLE. Platelet activation is observed in patients with SLE due to inflammatory cytokines and complement. There occurs consumption of large activated platelets in extravascular sites of inflammation. In this study we will understand the profile of SLE in patients presenting to a tertiary care hospital and we will correlate the role of NLR and MPV in identifying the SLE flare. Also, NLR and MPV are readily available even at a PHC, thus increasing the chances of identifying the SLE flare at every level of healthcare.