Recurrent/persistent primary hyperparathyroidism, clinical, pathological and genetic aspects

Completed

• Conditions: hyperactive parathyroid glands; primary hyperparathyroidism; 10033949

• Registration Number: NL-OMON32114
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 22 July 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 30

Inclusion Criteria

proven recurrent/persistent primary hyperparathyroidism after excision of one or more pathological parathyroid glands

Exclusion Criteria

primary hyperparathyroidism due to MEN syndrome, lithium use or parathyroid carcinoma, secundary or tertiary (autonomous) hyperparathyroidism due to long time vitamin D deficiency or chronic renal failure

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Clinical and biochemical parameters<br /><br>2. Pre-operative localization studies; MiBi-SPECT, PTH sampling<br /><br>3. Intra-operative PTH measurements<br /><br>4. Operative data<br /><br>5. Pathology data<br /><br>6. DNA analysis on leukocytes, formaline fixed paraffine imbedded (FFPE) tissue<br /><br>or frozen material </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>No secondary study parameters </p><br>