Airway Responses to Montelukast and Desloratadine.

Not Applicable

Completed

• Conditions: Asthma

• Registration Number: NCT00424580
• Lead Sponsor: University of Saskatchewan

Brief Summary

Montelukast (for asthma) and desloratadine (for allergies) are effective therapy for their current uses. Part of what happens when your allergies trigger your asthma should be prevented by either of these drugs. This project is being conducted to determine if these drugs are effective, either alone or in combination, on controlling asthma that is triggered by allergies.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-01
• Study First Submitted: 2007-01-18
• Study First Submitted QC: 2007-01-18
• Study First Posted: 2007-01-19
• Primary Completion: 2007-08
• Study Completion: 2007-08
• Status Verified: 2008-01
• Last Update Submitted: 2008-01-18
• Last Update Posted: 2008-01-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• baseline FEV1 > or = 65% predicted
• positive methacholine challenge (i.e. methacholine PC20 < or = 16mg/ml
• positive allergen challenge

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Exclusion Criteria

• negative skin prick test
• lung condition/disease other than asthma
• currently use montelukast and/or desloratadine

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Late asthmatic response (maximum percent decrease in FEV1)

Secondary Outcome Measures

Name	Time	Method
Early asthmatic response (maximum percent decrease in FEV1
Changes in sputum cell/mediator content
Changes in airway hyperresponsiveness (methacholine PC20)

Trial Locations

Locations (1)

Room 346 Ellis Hall; 🇨🇦 Saskatoon, Saskatchewan, Canada