Diagnostic Importance of the C-reactive Protein From Blood and Saliva in Children With Acute Appendicitis
Not yet recruiting
- Conditions
- Acute Appendicitis
- Interventions
- Diagnostic Test: Blood specimen collection for C-reactive protein (CRP) and WBC (white blood cells). Saliva specimen collection for analysis of CRP levels
- Registration Number
- NCT06051825
- Lead Sponsor
- University Hospital of Split
- Brief Summary
Diagnosing acute appendicitis in children is still a challenge even for experienced clinicians. Failure to recognize this acute condition can result in perforation, with consequent peritonitis, or misdiagnosis can result in negative appendectomies. C-reactive protein in blood can be elavated in children with acute appendicitis. The aim of this research is to compare the diagnostic value of C-reactive protein from the blood and saliva of children with acute appendicitis and to prove wheter the analysis of biomarker from saliva as a minimally invasive procedure can be sufficient for diagnosis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
- children with age from 5 to 17 with acute abdominal pain
- children with clinical signs of appendicitis
Exclusion Criteria
- previous diagnosis of chronic and/or malignant disease
- children wich had previous abdominal surgery
- pregnancy
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Patients without acute appendicitis Blood specimen collection for C-reactive protein (CRP) and WBC (white blood cells). Saliva specimen collection for analysis of CRP levels Patients without acute appendicitis, after laboratory, clinical and/or radiological exclusion of acute admittance Patients with acute appendicitis Blood specimen collection for C-reactive protein (CRP) and WBC (white blood cells). Saliva specimen collection for analysis of CRP levels Patients with acute appendicitis, after surgery and with pathohistological confirmation
- Primary Outcome Measures
Name Time Method Level of CRP in blood 72 hours Levels of CRP in blood as measured by ELISA test
- Secondary Outcome Measures
Name Time Method Level of CRP in saliva 72 hours Levels of CRP in saliva as measured by ELISA test