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Clinical Trials/NCT05279989
NCT05279989
Completed
Not Applicable

Healthy Weight and Stress Management Study

Arizona State University1 site in 1 country25 target enrollmentStarted: December 1, 2021Last updated:

Overview

Phase
Not Applicable
Status
Completed
Enrollment
25
Locations
1
Primary Endpoint
Waist Circumference measured by measuring tape

Overview

Brief Summary

Approximately 1 in 10 mid-life (age 35-64) Americans have mobility impairing disabilities. People with mobility impairing disabilities are defined using the World Health Organization criteria: community living adults with mobility impairment (e.g., amputation, spinal cord injury). Women with mobility impairing disabilities often struggle with stress, abdominal fat (measured as waist circumference), lack of muscle tissue (measured as handgrip strength) and high cardiometabolic risk. This study investigates the usefulness, acceptability, and effectiveness of two strategies to reduce stress, improve health habits, reduce abdominal fat and increase muscle tissue in mid-life women with mobility impairments. These strategies involve either gentle stretching and strengthening exercises or watching informative videos.

Detailed Description

About 1 in 10 mid-life (age 35-64) Americans have mobility impairing disabilities, steadily increasing due to medical and technological innovations. People with mobility impairing disabilities (PMI) are defined using the World Health Organization criteria, as community living adults with mobility impairment (e.g., amputation, spinal cord injury). Mid-life is a critical time for people to improve their current functioning and enhance healthy aging, by improving emotional health and increasing physical activity (PA). A review showed PA improves emotional and physical health among PMI. PMI have unique challenges to meeting PA guidelines; innovative strategies are needed to achieve emotional and physical benefits for optimal health and aging.

The higher prevalence of daily stress encountered by mid-life PMI is linked to emotional health and abdominal fat (cardiometabolic disease risk) that can lead to premature mortality. This is especially so for women with mobility impairment (WMI) who have higher prevalence of excess body fat, higher cardiometabolic risk, and are not eligible for most interventions that involve PA. PA interventions also increase muscle mass, which helps to prevent cardiometabolic conditions. Although vigorous PA may not be well-suited for WMI, lighter intensity PA such as Tai Chi, Qigong and Yoga-also called meditative movement-adapted for seated practice, are a possible solution.

Tai Chi and Qigong have been tested in non-impaired populations. Our work combines these two forms of low-to-moderate PA meditative movement, Tai Chi and Qigong (TCQ), in a mind-body practice. Our research, and others', show that TCQ consistently shows strong improvement in women in depressive symptoms, anxiety, emotional eating, and sleep quality-all contributing to excess abdominal fat (measured as waist circumference), improved muscle tissue (measured as handgrip strength) and strongly associated with cardiometabolic risk. Conventional health assessment strategies do not always work well for PMI; recent innovations have yielded scalable, low-contact assessment. We have demonstrated robust recruitment, reliable questionnaire administration and strong intervention implementation expertise via social media, video sharing, and gaming platforms.

Aim 1: Assess the potential efficacy of TCQ to reduce waist circumference and increase handgrip strength compared to controls from T1 to T2 and sustain this change to T3 and T4 when compared to control.

Aim 2: Assess the potential efficacy of TCQ to reduce stress-related behaviors (depressive symptoms, anxiety, emotional eating, and sleep) that impact abdominal fat and strength when compared to control.

Aim 3: Evaluate the feasibility and acceptability of an online delivered TCQ intervention in women with mobility impairments.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Prevention
Masking
None

Eligibility Criteria

Ages
35 Years to 64 Years (Adult)
Sex
Female
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Community dwelling.
  • Waist circumference \>83 cm (\~35 inches).
  • Have a self-reported mobility impairment due to a chronic (\>1 year).
  • Physically disabling condition (regularly using an assistive device).
  • Access to an email address and a working phone, mobile device, or personal computer or device with a high-speed internet connection.
  • Understand spoken and written English and be willing to be randomized.
  • Willing to engage in the intervention for 12 weeks, be available for two Zoom calls for data collection at T1, T2, T3, and T4 (Week 1, Week 4, Week 8, and Week 12).

Exclusion Criteria

  • People with full mobility.
  • People who have been regularly practicing (e.g., ≥2 or more times per month for the past 6 months) any form of meditative movement including, but not limited to, Yoga, Tai Chi or Qigong.
  • Pregnant, lactating, or planning to become pregnant in the next 6 months,
  • Participants outside of the age range will be excluded from participation.
  • Adults unable to consent and prisoners will be excluded.

Outcomes

Primary Outcomes

Waist Circumference measured by measuring tape

Time Frame: Week 12

Waist Circumference (cm) assessed by measuring tape

Handgrip strength measured by isokinetic handgrip dynamometry

Time Frame: Week 12

Weight (kg) resisted measured by handgrip dynamometer

Depressive Symptoms assessed by Center for Epidemiologic Studies Depression Scale

Time Frame: Week 12

Center for Epidemiologic Studies Depression Score ranging from 0-3, with lower scores indicating a more desirable outcome.

Anxiety assessed by Generalized Anxiety Disorder 7-item Scale

Time Frame: Week 12

Generalized Anxiety Disorder 7-item Scale Score ranging from 0-21, with lower scores indicating a more desirable outcome

Waist Circumference assessed by measuring tape

Time Frame: Week 4

Waist Circumference (cm) assessed by measuring tape

Secondary Outcomes

  • Well-Being assessed by the Short-Form Health Survey(Week 12)
  • Emotional Eating assessed by Mindful Eating Questionnaire - 5 Factor(Week 12)
  • Sleep Quality assessed by the Pittsburgh Sleep Quality Index(Baseline)
  • Sleep Quality assessed by Pittsburgh Sleep Quality Index(Week 12)
  • Food Consumption Frequency assessed by the Dietary Screener Questionnaire(Week 12)
  • Physical Functioning assessed by the Short-Form Health Survey(Baseline)
  • Physical Functioning assessed by The Short-Form Health Survey(Week 12)

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (1)

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