Role of Choline PET/CT in Predicting Survival in Patients With Hepatocellular Carcinoma
- Conditions
- Hepatocellular Carcinoma
- Registration Number
- NCT03430635
- Lead Sponsor
- Humanitas Clinical and Research Center
- Brief Summary
¹¹C-choline positron emission tomography/computed tomography (PET/CT) has been used in patients with some types of solid cancers, but few data are available in patients undergoing hepatectomy for hepatocellular carcinoma (HCC). The aim of this study was to analyze the prognostic value of metabolic imaging data by using ¹¹C-choline PET/CT in patients with HCC before hepatectomy.
- Detailed Description
Our prospectively maintained liver unit database was queried for patients with HCC preoperatively staged with ¹¹C-choline PET/CT. This metabolic imaging modality was performed in addition to standard abdominal CT or magnetic resonance imaging. Several PET/CT parameters were recorded and analyzed. Univariate and multivariate analyses were performed to identify whether those PET/CT parameters could be predictors of overall survival (OS) and disease-free survival (DFS) of HCC patients.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
- Any patient with HCC candidate to surgical resection preoperatively staged with ¹¹C-choline PET/CT
- R2 resection;
- Intraoperative use of RFA/MWI
- Postoperative death (90-days)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Identification of PET/CT parameters that can be predictors of survival From date of surgery until the date of first documented progression or date of death from any cause, whichever came first assessed up to 72 months Identification of specific PET/CT parameters that can be used as independent predictors of overall and/or disease-free survival
- Secondary Outcome Measures
Name Time Method