Evaluate the Predictive Impact of the MEESSI Score

Recruiting

• Conditions: Emergencies; Heart Diseases

• Registration Number: NCT05340972
• Lead Sponsor: University of Monastir

Brief Summary

Our primary purpose is to assess MEESSI score in predicting mortality and readmission of patients managed for acute heart failure (AHF) in Emergency Department.

European Society of Cardiology recommend risk stratification for patients with AHF.

Detailed Description

Improved risk stratification of acute heart failure (AHF) in the emergency department (ED) may help physicians' decisions regarding patient admission or early discharge disposition. The MEESSI-AHF (Multiple Estimation of risk based on the Emergency department Spanish Score In patients with AHF) score was developed to predict 30-day mortality in patients presenting with AHF EDs in Spain. Whether it performs well in other countries is unknown.

The MEESSI-AHF risk model includes 13 variables readily available on arrival to Emergency Department. The 40% of patients classified as LOW RISK (30-day mortality: \<2%) should be considered as potential candidates to be early discharged from Emergency Department without admission after adequate response to initial treatment. The 10% of patients classified as VERY HIGH RISK (30-day mortality: \>2%) may clearly benefit from hospital admission.

Objective: To externally validate the MEESSI-AHF score in another country.

Study Timeline

• Study Start: 2009-01-15
• Study First Submitted: 2022-04-07
• Study First Submitted QC: 2022-04-21
• Study First Posted: 2022-04-22
• Status Verified: 2023-05
• Last Update Submitted: 2023-05-13
• Last Update Posted: 2023-05-16
• Primary Completion: 2023-05-30
• Study Completion: 2023-05-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 1500

Inclusion Criteria

• Major patient
• Patient admitted to emergencies with final diagnosis of AHF according to the opinion of two emergency experts after consulting the data from the clinical examination, cardiac echocardiography, and BNP level.
• Subject who accept to participate in the research

Exclusion Criteria

• Patient who refuse to participate in the study
• Patient with coronary syndrome with ST segment elevation
• Other causes of dyspnea
• Impossibility of giving the patient informed information
• Pregnant woman

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
MEESSI score	30 days	predict the AHF patient's future in the month following management in ED with The MEESSI (Multiple Estimation of risk based on the Emergency department Spanish Score In patients with AHF).The MEESSI-AHF risk model includes 13 variables readily available on arrival to Emergency Department. The 40% of patients classified as LOW RISK (30-day mortality: \<2%) should be considered as potential candidates to be early discharged from Emergency Department without admission after adequate response to initial treatment. The 10% of patients classified as VERY HIGH RISK (30-day mortality: \>2%) may clearly benefit from hospital admission.

Secondary Outcome Measures

Name	Time	Method
Re-admission rate [ Time Frame: 30 days ]	30 days	30-day re-admission rate compared between the 4 risk categories defined by the MEESSI score
Mortality rate [ Time Frame: 30 days ]	30 days	Mortality rate at 30 days compared between the 4 risk categories defined by the MEESSI score
Sensitivity [ Time Frame: 30 days ]	30 days	Sensitivity, specificity and ROC curve of the MEESSI score in relation to the composite criterion according to the 4 risk categories

Trial Locations

Locations (1)

Emergency department of University hospital Fattouma Bourguiba; 🇹🇳 Monastir, Tunisia