NCT07100626进行中（未招募）不适用
In Situ Clinical Trial Investigating the Ability of BlueCheck to Detect and Monitor Active Carious Lesions and Their Remineralization
Incisive Technologies Pty Ltd1 个研究点 分布在 1 个国家目标入组 12 人开始时间: 2025年9月24日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Sensitivity of BlueCheck to detect early stage carious lesions
研究概览
简要总结
The goal of this clinical trial is to evaluate whether BlueCheck® can accurately detect and monitor early-stage dental caries (tooth decay) and their remineralization in adults. Participants will wear partial dentures with partially demineralized human enamel specimens. The main questions it aims to answer are:
- Can BlueCheck® reliably detect early carious lesions with high sensitivity and specificity?
- Does BlueCheck® visually reflect changes in remineralized enamel lesions?
BlueCheck® results will be compared against standard diagnostic methods (e.g., Nyvad criteria, Diagnodent readings, surface microhardness) to see if BlueCheck® provides an objective, accurate, and visual method of detecting and monitoring early-stage caries.
Participants will:
- Wear a modified lower partial denture with four mounted enamel specimens for 28 days.
- Use only the study-provided fluoride containing toothpaste
- Attend weekly clinic visits for removal and laboratory analysis of one enamel specimen per week.
- Undergo regular oral health checks and provide diary entries tracking brushing and any adverse events.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •provide voluntary, written informed consent;
- •be between 18 and 85 years old;
- •understand and be willing, able and likely to comply with all study procedures and restrictions;
- •be wearing a removable mandibular partial denture with sufficient room to accommodate four (4) human enamel specimens (4 mm round) in their partial denture on both sides (two specimens on each side, bilateral partial denture) or one side (4 specimens on one side, unilateral partial denture)
- •be willing and capable of wearing their removable partial denture 24 hours a day for four (4), one-week treatment periods, maximum total duration four (4) weeks;
- •be willing to allow study personnel to drill specimen sites in the posterior section of one or both sides of their lower partial denture (teeth and/or buccal flange area below the teeth); and
- •be in good medical and dental health with no active caries or periodontal disease.
- •have a salivary flow rate in the range of normal values (unstimulated whole saliva flow rate ≥ 0.2 mL/min; gum base stimulated whole saliva flow rate ≥ 0.8 mL/min).
排除标准
- •currently be pregnant (self-reported), intending to become pregnant during the study period or breast feeding;
- •currently have any medical condition that could be expected to interfere with the subject's safety during the study period;
- •currently be taking antibiotics or have taken antibiotics in the two weeks prior to the beginning treatment;
- •known or suspected intolerance or hypersensitivity to the study materials (or closely related compounds) or any of their stated ingredients;
- •have participated in another clinical study or receipt of an investigational drug within 30 days of beginning treatment; or
- •be taking fluoride supplements, required to use a fluoride mouthrinse or have received a professional fluoride treatment in the two weeks preceding specimen placement.
结局指标
主要结局
Sensitivity of BlueCheck to detect early stage carious lesions
时间窗: Day 0
BlueCheck will be applied to the early stage enamel carious lesions and visually assessed whether they are highlighted blue
Specificity of BlueCheck to not visual highlight sound enamel
时间窗: Day 0
BlueCheck will be applied to sound enamel samples and visually assessed whether they are highlighted blue.
次要结局
- Change in BlueCheck colouration of remineralised artificial carious lesions(Day 1, 7, 14, 21 and 28)
研究者
研究点 (1)
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