NCT01112033已完成不适用
Biliverdin Reductase A in Chronic Hepatitis C Virus Infection
Charles University, Czech Republic1 个研究点 分布在 1 个国家目标入组 113 人开始时间: 2010年6月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 113
- 试验地点
- 1
- 主要终点
- To assess differences in BLVRA expression in the liver and PBMC in HCV infected patients in responders and non-responders to standard antiviral therapy.
研究概览
简要总结
In this project, the investigators aim to study the role of biliverdin reductase A (BLVRA) in HCV infected patients prior and during/after standard antiviral therapy in association with viral clearance, disease progression and treatment response and in comparison with healthy subjects.
详细描述
- To analyze biliverdin reductase (BLVRA) expression in the liver of HVC infected patients undergoing liver biopsy followed by standard antiviral treatment (peg-interferon plus ribavirin combination therapy) and patients with other forms of liver diseases undergoing liver biopsy as controls.
- To analyze BLVRA expression in peripheral blood leukocytes (PBL) of therapeutically naïve HCV patients, during/after standard antiviral therapy and healthy controls.
- To analyze BVLRA genetic polymorphisms both in HCV infected patients and healthy controls.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BLVRA expression study
- •Therapeutically naïve HCV patients undergoing antiviral treatment with peg-interferon plus ribavirin combination therapy
- •BLVRA genetic polymorphisms study
- •HCV infected patients prior, during, after or without antiviral therapy
排除标准
- •Co-infection with HAV, HBV and HIV
- •Disorders of heme metabolism
结局指标
主要结局
To assess differences in BLVRA expression in the liver and PBMC in HCV infected patients in responders and non-responders to standard antiviral therapy.
时间窗: 72 weeks
次要结局
- To analyze the association of genetic polymorphisms of BLVRA with disease progression and treatment response in HCV infected patients.(3 years)
研究者
Iva Subhanova
Institute of Medical Biochemistry and Laboratory Diagnostics
Charles University, Czech Republic
研究点 (1)
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