Comparison of Clomiphene citrate and Letrozole using modified Uterine scoring system for reproduction during cycles of ovulation induction : A double blinded Randomised Control Trial

Primary purpose of the study is to compare the effects of Clomiphene citrate and Letrozole on the uterine body during cycles of ovulation induction.

Clomiphene Citrate and Letrozole are being used for ovulation induction for a long time. They have been extensively compared to find the most effective drug with least adverse effect on uterus. There have been numerous studies comparing number of follicles stimulated by these drugs, their effect on endometrial thickness, their associated beneficial and adverse effects. But no study has been found in literature to the best of our knowledge about their comprehensive effect on the entire uterine body. Hence, we aim to apply an objective scoring system i.e. Uterine Scoring System for Reproduction to compare the effects of these drugs. This scoring system includes the following aspects- endometrial thickness, morphology, vascularity, myometrial echogenicity and blood flow and uterine artery doppler thereby giving us a complete idea about the drug action and its effect on uterus.