The Pharmacokinetics of an oral uracil dose in patients with colorectal carcinoma.

Phase 2

Completed

• Conditions: DPD deficiency; 10027424

• Registration Number: NL-OMON34808
• Lead Sponsor: Scheper Ziekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 24

Inclusion Criteria

age > 18 year
extended disease
signed imformed consent
DPD activity in PBM >= 6 nmol/mg/uur
life expectation > 3 months

Exclusion Criteria

DPD activity in PBM < 6 nmol/mg/uur
pregnancy
breas fedding
use of Cimetidine
Kidney failure

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>AUC of uracil </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>n.a.</p><br>