The effect of oral Naloxone on Methadone induced constipatio

Phase 3

Recruiting

• Conditions: Drug induced constipation.; Constipation; K59.0

• Registration Number: IRCT20190207042648N2
• Lead Sponsor: Mashhad University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 17 August 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Participant in the MMT program for at least three months
Willingness to participate in research studies
Receive methadone less than 75 mg /day

Exclusion Criteria

Past history of GI surgery (Except Appendectomy)
History of Thyroid disease
History of diabetes mellitus.
Hypercalcemia
renal failure
using Tricyclic antidepressant
Using Calcium Chanel blockers
Hypertension
cardiac disease
Multi-drugs abuser
Using anticholinergic drugs
Pregnancy
Recently weight loss
More then 4 NVD or Past history of Severe labor
Parkinsonism

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
??Constipation score. Timepoint: At start, one and two weeks later (end of research). Method of measurement: Constipation Scoring System and Briston scoring.;Defecation in the three areas of abdominal, rectal and feces. Timepoint: At start , one and two weeks later ( end of research). Method of measurement: PAC-SYM questionnaire.

Secondary Outcome Measures

Name	Time	Method
Constipation scoring. Timepoint: At start , one and two weeks later ( end of research). Method of measurement: PAC-SYM questionnaire and Constipation Scoring System.;Opiate withdrawal scoring. Timepoint: One and two weeks later ( end of research). Method of measurement: opiate withdrawal scale.