Randomized, Double-blind Study of Efficacy and Safety of Bexotegrast (PLN-74809) for Idiopathic Pulmonary Fibrosis
- Conditions
- Idiopathic Pulmonary Fibrosis
- Interventions
- Drug: Placebo
- Registration Number
- NCT06097260
- Lead Sponsor
- Pliant Therapeutics, Inc.
- Brief Summary
A randomized, double-blind, dose-ranging, placebo-controlled study to evaluate the efficacy and safety of bexotegrast (PLN-74809) for the treatment of idiopathic pulmonary fibrosis (BEACON-IPF).
- Detailed Description
This is a randomized, double-blind, dose-ranging, placebo-controlled study to evaluate the efficacy and safety of 2 doses of bexotegrast (PLN-74809) \[160 and 320 mg\] taken for 52 weeks by participants with IPF taking and not taking background therapy (ie, nintedanib or pirfenidone).
The study will consist of an up to 35-day Screening Period, a 52-week Treatment Period, and a 14 day Safety Follow-up Period. Of note, participants who are not taking background therapy at study entry will be allowed to initiate it at any time during the study.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 360
- ≥ 40 years of age prior to screening
- IPF diagnosis ≤ 7 years prior to screening
- FVCpp ≥ 45%
- Diffusing capacity for carbon monoxide percent predicted (hemoglobin-adjusted) ≥ 30% and < 90%
- Current treatment for IPF with background therapy is allowed, if at a stable dose for ≥ 12 weeks prior to screening
- If not currently receiving treatment for IPF (either treatment naïve or discontinued prior treatment), participant must not have taken background therapy for at least 8 weeks prior to screening
- Receiving pharmacologic therapy for pulmonary hypertension
- Self-reported smoking of any kind (not limited to tobacco)
- History of malignancy within the past 5 years or ongoing malignancy other than basal cell carcinoma, resected noninvasive cutaneous squamous cell carcinoma, or treated cervical carcinoma in situ
- Hepatic impairment or end-stage liver disease
- Renal impairment or end-stage kidney disease requiring dialysis
- Pregnant or lactating female participant
- Uncontrolled systemic arterial hypertension
- Receiving any unapproved or investigational agent intended for treatment of fibrosis in IPF
- Prior administration of bexotegrast
- Likely to have lung transplantation during the study (being on transplantation list is not an exclusion)
- Forced expiratory volume in the first second (FEV1)/FVC ratio <0.7 at screening
- Clinical evidence of active infection, including, but not limited to bronchitis, pneumonia, or sinusitis that can affect FVC measurement during screening or at randomization
- Known acute IPF exacerbation, or suspicion by the Investigator of such, 6 months prior to screening
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Placebo Placebo Placebo Bexotegrast (PLN-74809) 160 mg Dose PLN-74809 Bexotegrast (PLN-74809) 160 mg Dose - 52 weeks Bexotegrast (PLN-74809) 320 mg Dose PLN-74809 Bexotegrast (PLN-74809) 320 mg Dose - 52 weeks
- Primary Outcome Measures
Name Time Method To characterize the effect of bexotegrast versus placebo on the change in forced vital capacity (FVC) in participants with idiopathic pulmonary fibrosis (IPF) 52 weeks Change from baseline in absolute FVC (mL) at Week 52
- Secondary Outcome Measures
Name Time Method Change from baseline in Living with Pulmonary Fibrosis (L-PF) Dyspnoea and Cough Domain score 52 Weeks The Living with Pulmonary Fibrosis (L-PF) questionnaire assesses symptoms and quality of life in patients with fibrosing interstitial lung diseases (ILDs). Its Dyspnoea and Cough domains, whose items' responses are based on a 24-hour recall, have scores ranging from 0 to 100, with higher scores indicating greater symptom severity. Domain and total scores range from 0 to 100, with higher scores indicating greater impairment.
To characterize the effect of bexotegrast versus placebo over 52 weeks of treatment on disease progression Up to 52 weeks • Time to disease progression, defined as time to first occurrence of ≥10% absolute decline from baseline in forced vital capacity percent predicted (FVCpp), adjudicated respiratory-related hospitalization, adjudicated acute IPF exacerbation or all-cause mortality through Week 52
Time to disease progression defined as Up to 52 weeks Time to first occurrence of adjudicated respiratory-related hospitalization, adjudicated acute IPF exacerbation or all-cause mortality through Week 52
Proportion of participants with disease progression defined as Up to 52 weeks Proportion of participants with a ≥10% absolute decline in FVCpp from baseline or all-cause mortality through Week 52
To characterize the effect of bexotegrast versus placebo on the change in FVC in participants with and without background therapy at baseline with IPF 52 weeks Change from baseline in absolute FVC (mL) at Week 52
* In participants on background therapy at baseline
* In participants not on background therapy at baselineChange from baseline in King's Brief Interstitial Lung Disease (K-BILD) questionnaire Total score 52 Weeks The KBILD(King's Brief Interstitial Lung Disease Questionnaire) is a self-completed health status questionnaire that comprises 15 items and a seven-point Likert response scale.1 It has three domains: psychological, breathlessness and activities and chest symptoms. The KBILD domain and total score ranges are 0-100; 100 represents best health status
To characterize the effect of bexotegrast versus placebo on change in lung fibrosis by high-resolution computed tomography 52 Weeks Absolute change from baseline in quantitative lung fibrosis (QLF) extent (%)
To characterize the safety and tolerability of bexotegrast versus placebo in participants with IPF Up to 52 weeks Proportion of participants with treatment-emergent adverse events and serious adverse events
To characterize the safety and tolerability of bexotegrast versus placebo in participants with IPF over 52 weeks of treatment Over 52 Weeks Number of participants with Adverse Events (AEs) Number of participants with Serious AEs (SAEs)
Trial Locations
- Locations (260)
The Lung Research Center
🇺🇸Chesterfield, Missouri, United States
Dynamic Drug Advancement
🇨🇦Ajax, Ontario, Canada
Baylor Scott and White Health - Advanced Lung Disease Specialists
🇺🇸Dallas, Texas, United States
El Paso Pulmonary Association
🇺🇸El Paso, Texas, United States
Sanatorio Parque de Rosario
🇦🇷Rosario, Santa Fe, Argentina
Hôpital Pontchaillou
🇫🇷Rennes, Ille-et-Vilaine, France
University of Alabama at Birmingham
🇺🇸Birmingham, Alabama, United States
Arizona Pulmonary Specialists
🇺🇸Phoenix, Arizona, United States
Dignity Health-St. Josephs Hospital and Medical Center
🇺🇸Phoenix, Arizona, United States
University of Arizona College of Medicine
🇺🇸Tucson, Arizona, United States
University of Southern California - Keck School of Medicine
🇺🇸Los Angeles, California, United States
Cedars Sinai Medical Center
🇺🇸Los Angeles, California, United States
Newport Native MD, Inc
🇺🇸Newport Beach, California, United States
Palmtree Clinical Research
🇺🇸Palm Springs, California, United States
VA Palo Alto Health Care System
🇺🇸Palo Alto, California, United States
Paradigm Clinical Research Institute Inc - ClinEdge
🇺🇸Redding, California, United States
University of California Davis Comprehensive Cancer Center
🇺🇸Sacramento, California, United States
UCSF Medical Center - Pulmonary Practice
🇺🇸San Francisco, California, United States
Jeffrey S. Sager, MD Medical Corporation
🇺🇸Santa Barbara, California, United States
Stanford Health Care
🇺🇸Stanford, California, United States
University of Colorado
🇺🇸Aurora, Colorado, United States
National Jewish Health Main Campus
🇺🇸Denver, Colorado, United States
Critical Care, Pulmonary and Sleep Associates
🇺🇸Lakewood, Colorado, United States
Nuvance Health Medical Practices, Pulmonary & Sleep Specialists
🇺🇸Danbury, Connecticut, United States
Yale New Haven Hospital - York Street Campus
🇺🇸New Haven, Connecticut, United States
MedStar Georgetown University Hospital
🇺🇸Washington, District of Columbia, United States
Malcom Randall VA Medical Center
🇺🇸Gainesville, Florida, United States
Mayo Clinic Jacksonville
🇺🇸Jacksonville, Florida, United States
Clinical Research Specialists, LLC
🇺🇸Kissimmee, Florida, United States
Clinical Site Partners - Leesburg
🇺🇸Leesburg, Florida, United States
Central Florida Pulmonary Group PA
🇺🇸Orlando, Florida, United States
GCP Clinical Research
🇺🇸Tampa, Florida, United States
Emory Clinic
🇺🇸Atlanta, Georgia, United States
Augusta University
🇺🇸Augusta, Georgia, United States
Northwestern Memorial Hospital
🇺🇸Chicago, Illinois, United States
Loyola University Medical Center
🇺🇸Maywood, Illinois, United States
IU Health Advanced Heart and Lung Care
🇺🇸Indianapolis, Indiana, United States
University of Kansas Medical Center
🇺🇸Kansas City, Kansas, United States
Lexington VA Medical Center
🇺🇸Lexington, Kentucky, United States
Norton Pulmonary Specialists
🇺🇸Louisville, Kentucky, United States
Tulane Medical Center
🇺🇸New Orleans, Louisiana, United States
University of Maryland Medical Center
🇺🇸Baltimore, Maryland, United States
The Johns Hopkins Hospital JHH
🇺🇸Baltimore, Maryland, United States
Massachusetts General Hospital - Pulmonary Associates
🇺🇸Boston, Massachusetts, United States
Brigham and Womans Hospital
🇺🇸Boston, Massachusetts, United States
Beth Israel Deaconess Medical Cente
🇺🇸Boston, Massachusetts, United States
Infinity Medical Research
🇺🇸North Dartmouth, Massachusetts, United States
University of Michigan Health System
🇺🇸Ann Arbor, Michigan, United States
Henry Ford Health System
🇺🇸Detroit, Michigan, United States
University of Minnesota Medical Center, Fairview
🇺🇸Minneapolis, Minnesota, United States
Mayo Clinic
🇺🇸Rochester, Minnesota, United States
Dartmouth Hitchcock Medical Center
🇺🇸Lebanon, New Hampshire, United States
Montefiore Medical Center Moses Division Hospital
🇺🇸Bronx, New York, United States
Icahn School of Medicine at Mount Sinai
🇺🇸New York, New York, United States
New York Presbyterian Hospital-Columbia University Medical Center
🇺🇸New York, New York, United States
Weill Cornell Medicine
🇺🇸New York, New York, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
PulmonIx, LLC
🇺🇸Greensboro, North Carolina, United States
Southeastern Research Center
🇺🇸Winston-Salem, North Carolina, United States
University of Cincinnati
🇺🇸Cincinnati, Ohio, United States
The Cleveland Clinic Foundation
🇺🇸Cleveland, Ohio, United States
OU Health Physicians
🇺🇸Oklahoma City, Oklahoma, United States
Bend Memorial Clinic/Summit Medical Group - Eastside
🇺🇸Bend, Oregon, United States
Legacy Good Samaritan Hospital
🇺🇸Portland, Oregon, United States
Clinical Research Associates Of Central PA , LLC
🇺🇸DuBois, Pennsylvania, United States
Penn State Health Milton S. Hershey Medical Center
🇺🇸Hershey, Pennsylvania, United States
Perelman Center for Advanced Medicine
🇺🇸Philadelphia, Pennsylvania, United States
University of Pittsburgh Medical Center
🇺🇸Pittsburgh, Pennsylvania, United States
Medical University of South Carolina
🇺🇸Charleston, South Carolina, United States
Velocity Clinical Research
🇺🇸Greenville, South Carolina, United States
Lowcountry Lung and Critical Care PA
🇺🇸North Charleston, South Carolina, United States
Clinical Trials Center of Middle Tennessee
🇺🇸Franklin, Tennessee, United States
Statcare Pulmonary Consultants - Knoxville
🇺🇸Knoxville, Tennessee, United States
University of Tennessee Medical Center
🇺🇸Knoxville, Tennessee, United States
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
Baylor College of Medicine
🇺🇸Houston, Texas, United States
Research Centers of America
🇺🇸McKinney, Texas, United States
Renovatio Clinical Research
🇺🇸The Woodlands, Texas, United States
Topline Clinical Research
🇺🇸Waxahachie, Texas, United States
University of Utah
🇺🇸Salt Lake City, Utah, United States
University of Vermont Medical Center
🇺🇸Burlington, Vermont, United States
INOVA Fairfax Medical Campus
🇺🇸Falls Church, Virginia, United States
Western Washington Medical Group
🇺🇸Everett, Washington, United States
Centro de Investigaciones Medicas Mar del Plata
🇦🇷Mar del Plata, Buenos Aires, Argentina
Instituto Ave Pulmo
🇦🇷Mar Del Plata, Buenos Aires, Argentina
Clinica Privada Independencia
🇦🇷Munro, Buenos Aires, Argentina
Centro Respiratorio Quilmes
🇦🇷Quilmes, Buenos Aires, Argentina
CEMER - Centro Medico de Enfermedades Respiratorias
🇦🇷Vicente López, Buenos Aires, Argentina
Centro de Investigacion Clinica-CEDIC
🇦🇷Ciudad Autonoma de Buenos Aires, Ciudad Autonoma Buenos Aires, Argentina
Centro Médico Dra de Salvo
🇦🇷Buenos Aires, Ciudad Autónoma De BuenosAires, Argentina
Instituto Médico de la Fundación Estudios Clínicos
🇦🇷Rosario, Santa Fe, Argentina
Pacific Lung Research Center
🇨🇦Vancouver, British Columbia, Canada
Centro Integral de Medicina Respiratoria (CIMER)
🇦🇷San Miguel De Tucumán, Tucumán, Argentina
Consultorios Médicos Organización de Buen Ayre SRL
🇦🇷Ciudad Autónoma de Buenos Aires, Argentina
Instituto de Medicina Respiratoria
🇦🇷Córdoba, Argentina
Fundacion Scherbovsky
🇦🇷Mendoza, Argentina
INSARES
🇦🇷Mendoza, Argentina
Royal Prince Alfred Hospital
🇦🇺Camperdown, New South Wales, Australia
Lung Research Qld
🇦🇺Chermside, Queensland, Australia
Respiratory Clinical Trials
🇦🇺Kent Town, South Australia, Australia
The Queen Elizabeth Hospital
🇦🇺Woodville South, South Australia, Australia
Box Hill Hospital
🇦🇺Box Hill, Victoria, Australia
Monash Medical Centre
🇦🇺Clayton, Victoria, Australia
Austin Health
🇦🇺Heidelberg, Victoria, Australia
The Alfred Hospital
🇦🇺Melbourne, Victoria, Australia
Fiona Stanley Hospital
🇦🇺Murdoch, Western Australia, Australia
TrialsWest
🇦🇺Spearwood, Western Australia, Australia
Institute for Respiratory Health - Midland
🇦🇺Midland, Australia
AZ Delta
🇧🇪Roeselare, West-Vlaanderen, Belgium
UZ Leuvan
🇧🇪Leuven, Belgium
Santa Casa de Misericordia de Belo Horizonte
🇧🇷Belo Horizonte, Minas Gerais, Brazil
Irmandade da Santa Casa de Misericórdia de Porto Alegre
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Hospital Ernesto Dornelles
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Hospital Nossa Senhora da Conceicao
🇧🇷Porto Alegre, Rio Grande Do Sul, Brazil
Hospital de Clinicas de Porto Alegre HCPA - PPDS
🇧🇷Porto Alegre, Brazil
Hospital São Lucas da PUCRS
🇧🇷Porto Alegre, Brazil
Kelowna Respirology and Allergy Research
🇨🇦Kelowna, British Columbia, Canada
Centre intégré de santé et de services sociaux (CISSS) de la Montérégie-Centre
🇨🇦Greenfield Park, Quebec, Canada
CIC Joliette
🇨🇦Saint-Charles-Borromee, Quebec, Canada
Centre d'investigation Clinique Mauricie
🇨🇦Trois-Rivieres, Quebec, Canada
CENRESIN
🇨🇱Quillota, Chile
Av. Providencia 1208 oficina 209
🇨🇱Santiago, Chile
CEC SpA
🇨🇱Santiago, Chile
Biocinetic
🇨🇱Santiago, Chile
Centro de Investigacion del Maule
🇨🇱Talca, Chile
The Second Hospital of Anhui Medical University
🇨🇳Hefei, Anhui, China
The First Affiliated Hospital of Guangzhou Medical University
🇨🇳Guangzhou, Guangdong, China
Nanfang Hospital of Southern Medical University
🇨🇳Guangzhou, Guangdong, China
The 3rd Hospital of Hebei Medical University
🇨🇳Shijiazhuang, Hebei, China
Yichang Central People's Hospital
🇨🇳Yichang, Hubei, China
The second Xiangya Hospital of Central South University
🇨🇳Changsha, Hunan, China
The Affiliated Hospital of Xuzhou Medical College
🇨🇳Xuzhou, Jiangsu, China
The First Affiliated Hospital of Nanchang University
🇨🇳Nanchang, Jiangxi, China
Qilu Hospital of Shandong University
🇨🇳Jinan, Shandong, China
West China Hospital, Sichuan University
🇨🇳Chengdu, Sichuan, China
Sichuan Academy of Medical Sciences · Sichuan Provincial People's Hospital
🇨🇳Chengdu, Sichuan, China
Tianjin Medical University General Hospital
🇨🇳Tianjin, Tianjin, China
Hangzhou First People's Hospital
🇨🇳Hangzhou, Zhejiang, China
Fakultni nemocnice Brno
🇨🇿Brno, Jihomoravský Kraj, Czechia
Fakultni Nemocnice Olomouc
🇨🇿Olomouc, Olomoucký Kraj, Czechia
Fakultni Thomayerova Nemocnice
🇨🇿Praha 4, Czechia
Odense Universitetshospital
🇩🇰Odense, Denmark
Aarhus Universitetshospital
🇩🇰Aarhus, Denmark
Gentofte Hospital
🇩🇰Hellerup, Denmark
Institut Coeur Poumon - CHU de Lille
🇫🇷Lille Cedex, Nord, France
CHU de Bordeaux- Hopital du Haut Lévêque
🇫🇷Bordeaux, France
CHU Lyon - Hôpital Cardio-Vasculaire et Pneumologique Louis Pradel
🇫🇷Lyon, France
Hôpital Nord - CHU Marseille
🇫🇷Marseille, France
CHU Arnaud de Villeneuve
🇫🇷Montpellier, France
CHU Nice - Hôpital Pasteur
🇫🇷Nice, France
Hopital Pasteur CHU Nice
🇫🇷Nice, France
Hospital Bretonneau
🇫🇷Paris, France
Hôpital Bichat - Claude Bernard
🇫🇷Paris, France
Hopital Haut-Leveque Pharmacie
🇫🇷Pessac, France
CHU Reims - Hôpital Maison Blanche
🇫🇷Reims, France
Hopital Larrey
🇫🇷Toulouse, France
LMU Klinikum der Universität München - Campus Großhadern
🇩🇪München, Bayern, Germany
Universitätsklinikum Gießen (UKGM)
🇩🇪Gießen, Hessen, Germany
Medizinische Hochschule Hannover
🇩🇪Hannover, Niedersachsen, Germany
Ruhrlandklinik
🇩🇪Essen, Nordrhein-Westfalen, Germany
Kliniken der Stadt Koln
🇩🇪Köln, Nordrhein-Westfalen, Germany
Krankenhaus Bethanien
🇩🇪Solingen, Nordrhein-Westfalen, Germany
Fachkrankenhaus Coswig
🇩🇪Coswig, Sachsen, Germany
Universitätsklinikum Schleswig-Holstein, Campus Kiel
🇩🇪Kiel, Schleswig-Holstein, Germany
Zentralklinik Bad Berka
🇩🇪Bad Berka, Thüringen, Germany
Evangelische Lungenklinik Berlin
🇩🇪Berlin, Germany
Fachkrankenhaus Coswig GmbH
🇩🇪Coswig, Germany
IKF Pneumologie GmbH & Co. KG
🇩🇪Frankfurt, Germany
Universitaetsklinikum des Saarlandes
🇩🇪Homburg, Germany
Universitaetsklinikum Leipzig AoeR
🇩🇪Leipzig, Germany
University General Hospital of Patras
🇬🇷Patras, Achaïa, Greece
Sotiria Thoracic Diseases Hospital of Athens
🇬🇷Athens, Attiki, Greece
University General Hospital of Alexandroupolis
🇬🇷Alexandroupoli, Evros, Greece
University General Hospital of Ioannina
🇬🇷Ioánnina, Ioannina, Greece
University General Hospital of Heraklion
🇬🇷Heraklion, Greece
University General Hospital of Larissa
🇬🇷Larissa, Greece
ESIC Medical College and Hospital
🇮🇳Faridabad, Haryana, India
K.L.E. Society's Dr. Prabhakar Kore Hospital and Medical Research Centre
🇮🇳Belgaum, Karnataka, India
BHS Lakeview Hospital
🇮🇳Belgaum, Karnataka, India
Bhatia Hospital
🇮🇳Mumbai, Maharashtra, India
Siddhi Hospital
🇮🇳Nashik, Maharashtra, India
J.L.N., Medical College and Attached Hospitals
🇮🇳Ajmer, Rajasthan, India
Midland Healthcare & Research Center
🇮🇳Lucknow, Uttar Pradesh, India
Calcutta Medical Research Institute
🇮🇳Kolkata, West Bengal, India
B. P. Poddar Hospital and Medical Research Limited
🇮🇳Kolkata, West Bengal, India
Barzilai Medical Center
🇮🇱Ashkelon, HaDarom, Israel
Kaplan Medical Center
🇮🇱Reẖovot, HaMerkaz, Israel
Tel Aviv Sourasky Medical Center
🇮🇱Ashkelon, Tel-Aviv, Israel
Sheba Medical Center
🇮🇱Ramat Gan, Tel-Aviv, Israel
Shaare Zedek Medical Center
🇮🇱Jerusalem, Yerushalayim, Israel
Soroka University Medical Center
🇮🇱Beer-Sheva, Israel
Lady Davis Carmel Medical Center
🇮🇱Haifa, Israel
Rambam Medical Center
🇮🇱Haifa, Israel
Meir Medical Center
🇮🇱Kfar-Saba, Israel
Rabin Medical Center
🇮🇱Petach Tikva, Israel
Ospedale San Giuseppe Multimedica SpA
🇮🇹Milan, Milano, Italy
Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo
🇮🇹Alessandria, Italy
ASST Papa Giovanni XXIII - Azienda Ospedaliera Papa Giovanni XXIII
🇮🇹Bergamo, Italy
Azienda Ospedaliera Universitaria Careggi
🇮🇹Firenze, Italy
Azienda Ospedaliero-Universitaria Ospedali Riuniti di Foggia
🇮🇹Foggia, Italy
Policlinico Universitario Fondazione Agostino Gemelli - Roma
🇮🇹Roma, Italy
NHO Kyushu Medical Center
🇯🇵Fukuoka-shi, Fukuoka-Ken, Japan
Fukuoka University Hospital
🇯🇵Fukuoka-shi, Fukuoka-Ken, Japan
Aso Co.,Ltd Iizuka Hospital
🇯🇵Iizuka-shi, Fukuoka-Ken, Japan
Hospital of the University of Occupational and Environmental Health
🇯🇵Kitakyushu-shi, Fukuoka-Ken, Japan
Fukushima Medical University Hospital
🇯🇵Fukushima-shi, Fukushima-Ken, Japan
Hiroshima Prefectural Hospital
🇯🇵Hiroshima-shi, Hiroshima-Ken, Japan
Sapporo Medical University Hospital
🇯🇵Sapporo-shi, Hokkaido, Japan
Kobe City Hospital Organization
🇯🇵Kobe-shi, Hyogo-Ken, Japan
Center General Hospital
🇯🇵Kobe-shi, Hyogo-Ken, Japan
NHO Ibarakihigashi National Hospital
🇯🇵Naka-gun, Ibaraki-Ken, Japan
Kanagawa Cardiovascular and Respiratory Center
🇯🇵Yokohama-shi, Kanagawa-Ken, Japan
Kumamoto University Hospital
🇯🇵Kumamoto-shi, Kumamoto-Ken, Japan
Okayama University Hospital
🇯🇵Okayama-shi, Okayama-Ken, Japan
NHO Kinki-Chuo Chest Medical Center
🇯🇵Osaka-shi, Osaka-Fu, Japan
Saitama Prefectural Cardiovascular and Respiratory Center
🇯🇵Kumagaya-shi, Saitama-Ken, Japan
Saitama Red Cross Hospital
🇯🇵Saitama-shi, Saitama-Ken, Japan
Shimane University Hospital
🇯🇵Izumo-shi, Shimane-Ken, Japan
Hamamatsu University School of Medicine, University Hospital
🇯🇵Hamamatsu-shi, Shizuoka-Ken, Japan
Institute of Science Tokyo Hospital
🇯🇵Bunkyo-ku, Tokyo-To, Japan
Nippon Medical School Hospital
🇯🇵Bunkyo-ku, Tokyo-To, Japan
Juntendo University Hospital
🇯🇵Minato-Ku, Tokyo-To, Japan
Inje University Busan Paik Hospital
🇰🇷Busan, Gyeongsangnamdo, Korea, Republic of
Korea University Anam Hospital
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Hanyang University Medical Center
🇰🇷Seoul, Seoul Teugbyeolsi, Korea, Republic of
Inje University Haeundae Paik Hospital
🇰🇷Busan, Korea, Republic of
Severance Hospital, Yonsei University Health System
🇰🇷Seoul, Korea, Republic of
The Catholic University of Korea, Seoul St. Mary's Hospital
🇰🇷Seoul, Korea, Republic of
VU Medisch Centrum
🇳🇱Amsterdam, Noord-Holland, Netherlands
St. Antonius Ziekenhuis
🇳🇱Nieuwegein, Utrecht, Netherlands
Christchurch Hospital
🇳🇿Christchurch, Canterbury, New Zealand
Greenlane Clinical Centre
🇳🇿Auckland, North Island, New Zealand
Dunedin Hospital
🇳🇿Dunedin, Otago, New Zealand
Waikato Hospital
🇳🇿Hamilton, Waikato, New Zealand
Twoja Przychodnia NCM
🇵🇱Nowa Sól, Lubuskie, Poland
Vitamed Galaj i Cichomski sp.j.
🇵🇱Bydgoszcz, Poland
Uniwersyteckie Centrum Kliniczne
🇵🇱Gdańsk, Poland
SP ZOZ Szpital Uniwersytecki w Krakowie
🇵🇱Kraków, Poland
IP Clinic Sp. z o. o.
🇵🇱Łódź, Poland
Hospital de Braga
🇵🇹Braga, Portugal
Centro Hospitalar de Lisboa Central, E.P.E - Hospital de Santa Marta
🇵🇹Lisbon, Portugal
Centro Hospitalar Vila Nova de Gaia/Espinho, E.P.E.
🇵🇹Vila Nova de Gaia, Portugal
Hospital Universitario Puerta de Hierro - Majadahonda
🇪🇸Majadahonda, Madrid, Spain
Hospital Universitari de Bellvitge
🇪🇸Barcelona, Spain
Hospital Universitario Puerta de Hierro Majadahonda
🇪🇸Majadahonda, Spain
Hospital Clinico Universitario Virgen de la Victoria
🇪🇸Málaga, Spain
CHUS - H. Clinico U. de Santiago
🇪🇸Santiago De Compostela, Spain
Kaohsiung Medical University - Chung-Ho Memorial Hospital
🇨🇳Kaohsiung City, Taiwan
China Medical University Hospital
🇨🇳Taichung, Taiwan
Taichung Veterans General Hospital
🇨🇳Taichung, Taiwan
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Taipei Veterans General Hospital
🇨🇳Taipei, Taiwan
Far Eastern Memorial Hospital
🇨🇳Taipei, Taiwan
Altnagelvin Area Hospital
🇬🇧Londonderry, Derry, United Kingdom
Southampton General Hospital
🇬🇧Southampton, Hampshire, United Kingdom
Western General Hospital
🇬🇧Edinburgh, Lothian Region, United Kingdom
Castle Hill Hospital
🇬🇧Cottingham, North Humberside, United Kingdom
Pinderfields General Hospital
🇬🇧Wakefield, West Yorkshire, United Kingdom
Birmingham Heartlands Hospital
🇬🇧Birmingham, United Kingdom
Royal Brompton Hospital
🇬🇧London, United Kingdom