Enhancing Motor Learning with a Single Dose of Modafinil or Fluoxetine
Recruiting
- Conditions
- n.a.10028037
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 166
Inclusion Criteria
Healthy
Male
Aged 18-55 years
Informed consent obtained
Exclusion Criteria
History of neurological or psychiatric disorders
History of neurosurgery
History of Sleep disorders
History or evidence of renal, gastrointestinal, hepatic or hematologic abnormalities
Using acute or chronic psychoactive drugs
Alcoholism
Smoking
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The main objective of the study is to determine the effect of modafinil and<br /><br>fluoxetine on motor learning in healthy individuals. The participants will be<br /><br>subjected to two different cerebellar specific motor adaptation paradigms: the<br /><br>random saccade adaption task (motor timing independent) and the random smooth<br /><br>pursuit adaptation task (motor timing dependent). The motor learning capacity<br /><br>will be determined by quantifying the velocity and gain of adaptation. A<br /><br>minimal drug-induced improvement of the motor learning capacity by 10% is<br /><br>considered clinically relevant.</p><br>
- Secondary Outcome Measures
Name Time Method <p>n.a.</p><br>