D0904 - A Pilot Study of Bevacizumab (Avastin) in Patients With Unresectable or Recurrent Hemangioblastoma From Von Hippel-Lindau Disease.
试验速览
- 阶段
- 早期 1 期
- 状态
- 终止
- 入组人数
- 1
- 试验地点
- 2
- 主要终点
- Radiographic response in the size of the hemangioblastoma on magnetic resonance imaging (MRI)
研究概览
简要总结
Von Hippel-Lindau (VHL) disease is an inherited syndrome manifested by a variety of benign and malignant tumors. Hemangioblastomas are the most common lesion associated with VHL disease affecting 60-84% of patients with a mean age at diagnosis of 29 years. Standard treatment for this disease is by surgery or radiotherapy. No approved systemic therapy yet exists. Patients with VHL have an increased growth factor production, specifically vascular endothelial growth factor (VEGF), resulting in angiogenesis (growth of blood vessels). Studies show that Bevacizumab inhibits the growth of VEGF protein and will block the VEGF-driven angiogenesis and result in stabilization and regression of hemangioblastomas in VHL disease patients. The dose of bevacizumab will be 10 mg/kg every two weeks for up to 6 months.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •One or more CNS hemangioblastomas not amendable to surgical resection or recurrent post resection
- •Confirmed diagnosis of von-Hippel-Lindau disease
- •No prior treatment with VEGF inhibitors
- •Index hemangioblastomas lesion at least 5mm on MRI
- •No major bleeding event from hemangioblastoma within 90 days
- •KPS > or equal to 60%
- •Age > or equal to 18 years
排除标准
- •Prior treatment with VEGF inhibitors
- •Major bleeding event from hemangioblastoma within 90 days
- •Inability to comply with study and/or follow up procedures
- •Life expectancy of less than 12 weeks
- •Current or recent (within 4 weeks of the first infusion of this study) participation in an experimental drug study other than a Genentech sponsored bevacizumab cancer study
- •Active malignancy will be permissible if treating physician deems that concurrent administration of bevacizumab is not contraindicated and that the patient would be able to complete with the other parameters of the protocol
结局指标
主要结局
Radiographic response in the size of the hemangioblastoma on magnetic resonance imaging (MRI)
时间窗: 24 months
次要结局
- Changes in VEGF with bevacizumab treatment assist in the predication of radiographic response. Products of the HIF-1A synthesis pathway: plasma VEGF, PDGF, TGF-a and erythropoietin.(24 months)