Lipid Profile of Full-term Infants on Different Feeding Regimen: a Comparative Study
试验速览
- 阶段
- 不适用
- 入组人数
- 300
- 主要终点
- comparison between lipid profiles of the infants of the 3 groups
研究概览
简要总结
Lipid profile of full-term infants on different regimens. The aim of the study is to compare infant's lipid profiles on different feeding regimen during the first 6 months of life and its correlation with their mothers' lipid profiles (exclusive breastfeeding and mixed feeding) and to compare infants' lipid profiles on different feeding regimen with each other (including those on exclusive formula feeding).
详细描述
Infant and young child feeding is critical for their health and survival. Based on well-established evidence, the World Health Organization (WHO) and the United Nations Children's fund (UNICEF) recommend that mothers put newborns to the breast within one hour of birth, breastfeed infants exclusively for the first six months and continue to breastfeed for two years and beyond, together with nutritionally adequate, safe, age-appropriate, responsive feeding of solid, semi-solid and soft food starting in the sixth month.
For the first six months of life, breast milk alone is the ideal nourishment, providing all of the nutrients including minerals and fat soluble vitamins, an infant needs, meaning that no other liquid or food is needed.
In addition to providing a generally adequate nutrient supply that support normal growth and development , breastfeeding has been linked to multiple other advantages including a reduced risk of infection and long-term benefits for the risk of obesity, type II diabetes mellitus, blood pressure and better performance in intelligence tests.
The macro-nutrient composition of human milk varies within mothers according to nutritional status and across lactation. The mean macro-nutrient composition of mature, term milk is estimated to be approximately 0.9 to 1.2 gm/dl for proteins, 3.2 to 3.6 gm/dl for fats and 6.7 to 7.8 gm/dl for lactose.
There have been several systematic reviews supporting the positive effects of breastfeeding on cardiovascular risk factors, such as obesity and type 2 diabetes (DMII), hypertension. Breastfeeding also reduces plasma levels of total cholesterol (TC) and low density lipoprotein (LDL).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 12 Weeks 至 6 Months(Child)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Apparently healthy infants during the first 6 months of life on different feeding regimen
排除标准
- •Infants with perinatal problems .e.g.,
- •birth asphyxia
- •premature rupture of membranes
- •hypoglycemia
- •hypothermia
- •meconium stained amniotic fluid
- •pathological jaundice
- •congenital malformations
- •clinical evidence of chromosomal abnormalities
- •Infants born to mothers having any chronic disease e.g.,
- •diabetes mellitus
- •gestational diabetes
- •hypertension
- •pre-eclampsia
- •eclampsia
- •hypo/hyperthyroidism
- •on any long-term medication
结局指标
主要结局
comparison between lipid profiles of the infants of the 3 groups
时间窗: baseline
analysis of the results of lipid profiles of infants on different feeding regimens at the age of 14 weeks and 6 months
correlation of lipid profiles of infants and their mothers
时间窗: baseline
analysis of the results of lipid profiles of infants on exclusive breast feeding and mixed feeding (breast and formula feeding) and the results of lipid profiles of their mothers
次要结局
未报告次要终点
研究者
Maria Remon Riad Sedrak
Doctor
Assiut University
