Digital Intervention to Promote Physical Activity and Improve Cardiovascular Health Among Cancer Survivors
Overview
- Phase
- Phase 1
- Intervention
- HeartPhone app
- Conditions
- Breast Cancer
- Sponsor
- Penn State University
- Enrollment
- 3
- Locations
- 1
- Primary Endpoint
- Physical activity volume
- Status
- Terminated
- Last Updated
- 5 years ago
Overview
Brief Summary
This is a behavioral study that will examine changes in physical activity and vascular health in response to a digital tool (app) that will appear on participant's lock screen of their Android phone. Participants will be asked to use this app for 3 months and to wear a Fitbit device continuously throughout the study. Participants will be asked to complete questionnaires, participate in fitness testing and measures of cardiovascular health at 3 months and 6 months after baseline assessments. The hypothesis is that exposure to the app will lead to increased physical activity volume and improved microvessel function.
Investigators
David E Conroy
Professor
Penn State University
Eligibility Criteria
Inclusion Criteria
- •Age 18-65 years
- •Diagnosis of breast cancer, leukemia, or lymphoma \<15 yrs
- •Completed chemotherapy with cardiotoxic anthracycline-based agents 1+ year ago
- •English-proficiency
- •Own \& use smartphone with Android operating system
- •Main Study and Ancillary Study
Exclusion Criteria
- •Currently receiving curative treatment for cancer
- •90+ min/week moderate (or greater) intensity PA
- •Any medical contraindications on the Physical Activity Readiness Questionnaire
- •Require an assistive device for mobility or has any other condition that may limit or prevent participation in moderate-intensity physical activity
- •Current smoker
- •Pregnant or planning to become pregnant in the next 6 mos/breastfeeding
- •Allergy to test substances
- •Allergy to latex
- •Ancillary Study:
- •Taking metformin
Arms & Interventions
HeartPhone Intervention
Participants install the HeartPhone app on their smartphone. This app presents an image on a splash screen every time they activate their device. The image is randomly drawn from an image bank in the app. Repeated exposure to the image is designed to condition a more favorable automatic affective evaluation of physical activity and lead to increased physical activity.
Intervention: HeartPhone app
HeartPhone Intervention
Participants install the HeartPhone app on their smartphone. This app presents an image on a splash screen every time they activate their device. The image is randomly drawn from an image bank in the app. Repeated exposure to the image is designed to condition a more favorable automatic affective evaluation of physical activity and lead to increased physical activity.
Intervention: Acetylcholine
HeartPhone Intervention
Participants install the HeartPhone app on their smartphone. This app presents an image on a splash screen every time they activate their device. The image is randomly drawn from an image bank in the app. Repeated exposure to the image is designed to condition a more favorable automatic affective evaluation of physical activity and lead to increased physical activity.
Intervention: Sodium Nitroprusside
HeartPhone Intervention
Participants install the HeartPhone app on their smartphone. This app presents an image on a splash screen every time they activate their device. The image is randomly drawn from an image bank in the app. Repeated exposure to the image is designed to condition a more favorable automatic affective evaluation of physical activity and lead to increased physical activity.
Intervention: L-Arginine, N2-((4-Methylphenyl)Sulfonyl)-, Methyl Ester
Outcomes
Primary Outcomes
Physical activity volume
Time Frame: 3 month
Daily step counts over 1-week from Fitbit device
Secondary Outcomes
- Microvessel function(3 month)