Digital Intervention to Promote Physical Activity and Improve Cardiovascular Health Among Cancer Survivors
试验速览
- 阶段
- 1 期
- 状态
- 终止
- 入组人数
- 3
- 试验地点
- 1
- 主要终点
- Physical activity volume
研究概览
简要总结
This is a behavioral study that will examine changes in physical activity and vascular health in response to a digital tool (app) that will appear on participant's lock screen of their Android phone. Participants will be asked to use this app for 3 months and to wear a Fitbit device continuously throughout the study. Participants will be asked to complete questionnaires, participate in fitness testing and measures of cardiovascular health at 3 months and 6 months after baseline assessments. The hypothesis is that exposure to the app will lead to increased physical activity volume and improved microvessel function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-65 years
- •Diagnosis of breast cancer, leukemia, or lymphoma <15 yrs
- •Completed chemotherapy with cardiotoxic anthracycline-based agents 1+ year ago
- •English-proficiency
- •Own & use smartphone with Android operating system
- •Main Study and Ancillary Study
排除标准
- •Currently receiving curative treatment for cancer
- •90+ min/week moderate (or greater) intensity PA
- •Any medical contraindications on the Physical Activity Readiness Questionnaire
- •Require an assistive device for mobility or has any other condition that may limit or prevent participation in moderate-intensity physical activity
- •Current smoker
- •Pregnant or planning to become pregnant in the next 6 mos/breastfeeding
- •Allergy to test substances
- •Allergy to latex
- •Ancillary Study:
- •Taking metformin
- •Current medications that could conceivably alter the cardiovascular or thermoregulatory control or responses (e.g. beta blockers, calcium channel blockers, angiotensin receptor blockers)
研究组 & 干预措施
HeartPhone Intervention
Participants install the HeartPhone app on their smartphone. This app presents an image on a splash screen every time they activate their device. The image is randomly drawn from an image bank in the app. Repeated exposure to the image is designed to condition a more favorable automatic affective evaluation of physical activity and lead to increased physical activity.
干预措施: HeartPhone app (Behavioral)
HeartPhone Intervention
Participants install the HeartPhone app on their smartphone. This app presents an image on a splash screen every time they activate their device. The image is randomly drawn from an image bank in the app. Repeated exposure to the image is designed to condition a more favorable automatic affective evaluation of physical activity and lead to increased physical activity.
干预措施: Acetylcholine (Drug)
HeartPhone Intervention
Participants install the HeartPhone app on their smartphone. This app presents an image on a splash screen every time they activate their device. The image is randomly drawn from an image bank in the app. Repeated exposure to the image is designed to condition a more favorable automatic affective evaluation of physical activity and lead to increased physical activity.
干预措施: Sodium Nitroprusside (Drug)
HeartPhone Intervention
Participants install the HeartPhone app on their smartphone. This app presents an image on a splash screen every time they activate their device. The image is randomly drawn from an image bank in the app. Repeated exposure to the image is designed to condition a more favorable automatic affective evaluation of physical activity and lead to increased physical activity.
干预措施: L-Arginine, N2-((4-Methylphenyl)Sulfonyl)-, Methyl Ester (Drug)
结局指标
主要结局
Physical activity volume
时间窗: 3 month
Daily step counts over 1-week from Fitbit device
次要结局
- Microvessel function(3 month)
研究者
David E Conroy
Professor
Penn State University