Perioperative Factors and Early Postoperative Kidney Graft Function Recovery

Completed

• Conditions: Heart Injuries; Kidney Transplant; Complications
• Interventions: Procedure: Remote ischemic conditioning

• Registration Number: NCT06280898
• Lead Sponsor: Seoul St. Mary's Hospital

Brief Summary

Divided into two groups based on acute kidney injury: non-acute kidney injury group vs. non-acute kidney injury group. Acute kidney injury group, Acute Kidney Injury Network (AKIN), Risk, Injury, Failure, Loss of kidney function, and End-stage kidney disease (RIFLE), or Kidney Disease: Improving Global Outcomes (KDIGO) I would like to divide it according to the definition. After testing the normal distribution of patients, donors, grafts, types of immunosuppressants, surgery/anesthesia factors, and blood test findings between the two groups through the Shapiro-Wilk test, continuous data was tested using the student t-test or Mann-Whitney U test. Sizes are compared using , and categorical data is compared with proportions using the χ2 test or Fisher's exact test. Analysis of factors related to acute kidney injury will be performed through univariate and multivariate logistic regression analysis.

Detailed Description

Not available

Study Timeline

• Study Start: 2020-05-01
• Primary Completion: 2022-03-14
• Study Completion: 2022-03-14
• Status Verified: 2024-02
• Study First Submitted: 2024-02-16
• Study First Submitted QC: 2024-02-25
• Last Update Submitted: 2024-02-27
• Study First Posted: 2024-02-28
• Last Update Posted: 2024-02-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 539

Inclusion Criteria

• Adult patients aged 19 years or older who underwent kidney transplant surgery in the operating room

Exclusion Criteria

• Pediatric patients under 19 years of age
• Patients with multiple organ transplants, including kidney transplants
• Patients undergoing re-kidney transplant surgery
• Patient examination findings missing from electronic medical record

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
ischemic	Remote ischemic conditioning	-

Primary Outcome Measures

Name	Time	Method
Troponin I	up to 24 hour postoperatively	Troponin I difference in two groups

Secondary Outcome Measures

Name	Time	Method
QTc interval	up to 24 hour postoperatively	OTc interval difference in two groups
Troponin T	up to 24 hour postoperatively	Troponin T difference in two groups

Trial Locations

Locations (1)

Seoul St. Mary's hospital; 🇰🇷 Seoul, Korea, Republic of