Comparison of LASER Therapy and Desensitizing Agents in Dentinal Hypersensitivity

Not Applicable

Not yet recruiting

• Conditions: Dentinal Hypersensitivity
• Interventions: Drug: Glutaraldehyde-Based Desensetizing Agent; Device: Low Level Laser Therapy

• Registration Number: NCT06759454
• Lead Sponsor: Kemia Gul

Brief Summary

This study evaluates the effectiveness of laser therapy versus desensitizing agents in reducing pain among participants with dentinal hypersensitivity conducted in Saidu College of Dentistry. Pain will be measured at baseline, immediately post-treatment, one week, and three months using the Visual Analog Scale (VAS)

Detailed Description

This study examines dentinal hypersensitivity treatment modalities, including laser therapy and desensitizing agents. The study is conducted in compliance with regional ethical guidelines

Study Timeline

• Study First Submitted: 2024-12-28
• Study First Submitted QC: 2025-01-03
• Study First Posted: 2025-01-06
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-07
• Last Update Posted: 2025-05-11
• Study Start: 2025-06-30
• Primary Completion: 2025-12-31
• Study Completion: 2026-06-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 172

Inclusion Criteria

• Participants aged 18-50 years with a preoperative VAS score of ≥2 for dentinal hypersensitivity.
• Participants with sensitivity due to gingival recession, cervical abrasion, or enamel erosion.
• Participants with good systemic health.
• Minimum of two hypersensitive teeth present in two different quadrants.

Exclusion Criteria

• Teeth with caries, defective restorations, or cervical defects > 2 mm (may affect sensitivity measurements).
• Periodontal surgery or deep periodontal pockets (> 6 mm) within the past three months (potential influence on periodontal health and sensitivity).
• Participants using desensitizing toothpaste within the past three months (could interfere with study outcomes).
• Presence of gross oral pathology or systemic diseases (e.g., eating disorders, chronic diseases, uncontrolled metabolic conditions) (may alter oral health status).
• Pregnant or lactating women (hormonal changes can influence oral health).

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Arm 1 (Desensitizing Agent)	Glutaraldehyde-Based Desensetizing Agent	A glutaraldehyde-based desensitizing agent applied to affected teeth for 30 seconds, air-dried, with post-application instructions
Arm 2 (Laser Therapy)	Low Level Laser Therapy	Diode laser set to 100 mW in continuous wave mode, applied to specific areas of affected teeth for three minutes

Primary Outcome Measures

Name	Time	Method
Change in pain intensity: Visual Analog Scale	Immediately post-treatment, one week, and three months	After intervention there is a possibility of change in pain intensity in Dentinal Hypersensitivity

Trial Locations

Locations (1)

Saidu College of Dentistry; 🇵🇰 Swat, KPK, Pakistan