Characterization of Peripheral Muscle Function in Patients With Non-small-cell Lung Cancer

• Conditions: Non-Small-cell Lung Cancer

• Registration Number: NCT01885754
• Lead Sponsor: Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec

Brief Summary

Rationale: With 1.6 million new cases diagnosed each year and 1.3 million deaths, lung cancer is the leading cancer-related death worldwide and it represents a pressing health issue. Patients with lung cancer are more likely to experience cachexia, a severe debilitating disorder causing fatigue, weight loss, muscle wasting and associated with reduced physical function, increased chemotherapy toxicity and reduced survival. This syndrome occurring in about 80% of advanced cancer patients is the direct cause of death in about 20% of cases. However, despite the importance of cachexia in lung cancer, its mechanisms ans its relation with muscle function and effort tolerance are still unknown.

Aim: To explore muscle function, signaling pathways and its relationship to impaired functional capacity of patients with non-small-cell lung cancer(NSCLC); depending of whether they have cachexic state at diagnosis.

Methods: This study will be conducted at the Institut universitaire de cardiologie et de pneumologie de Québec. 56 patients newly diagnosed of NSCLC will be recruited and separated whether or not they have a cachexic state. The evaluation will need two visits separated by 5 days.

During the evaluation the following tests will be done:

* Anthropometric measures

* Level of daily physical activity

* Pulmonary function test

* Maximal incremental cardiopulmonary exercise test on ergocycle

* Endurance test on ergocycle

* Muscle function tests

* Magnetic stimulation

* Quadriceps biopsy

Detailed Description

Not available

Study Timeline

• Study Start: 2013-02
• Study First Submitted: 2013-02-13
• Study First Submitted QC: 2013-06-24
• Study First Posted: 2013-06-25
• Status Verified: 2017-01
• Last Update Submitted: 2017-01-05
• Last Update Posted: 2017-01-06
• Primary Completion: 2017-07
• Study Completion: 2017-10

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 56

Inclusion Criteria

• Men and women with a primary lung cancer diagnosis

Exclusion Criteria

• Already have undertaken surgery, chemotherapy or radiotherapy treatment
• Having an other cancer in the last five years
• Taking anticoagulation therapy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Maximal quadriceps strength	1 day (at the time of the diagnosis before any treatment)

Secondary Outcome Measures

Name	Time	Method
Exercise capacity	1 day (at the time of the diagnosis before any treatment)

Trial Locations

Locations (1)

Institut universitaire de cardiologie et de pneumologie de Québec; 🇨🇦 Québec, Quebec, Canada