VENOUS: A Translational Study of Enterococcal Bacteremia
- Conditions
- Enterococcal Bacteremia
- Registration Number
- NCT04410276
- Brief Summary
The purpose of this study is to assemble a multicenter prospective cohort of patients with enterococcal bloodstream infections (BSIs) to provide data on outcomes of patients with enterococcal BSIs for sample size calculations for future trials, as well as to characterize enterococcal isolates causing BSIs in order to comprehensively dissect the molecular epidemiology of infecting organisms for future studies.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 1000
- Hospitalized patient
- ≥1 positive blood culture with Enterococcus spp. (VRE or VSE) during hospitalization
- bacterial isolate(s) is/are available for further characterization
- Repeat blood culture(s) within 7 days from the first positive culture
- Cultures obtained from patients not admitted to the hospital
- Isolate(s) not available for further studies.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method All-cause, in-hospital mortality 30 days or until hospital discharge Death by any cause while patient is in the hospital
- Secondary Outcome Measures
Name Time Method Number of participants with recurrence of bacteremia 14 days after the documented eradication of bacteremia Positive blood culture with the same organism within the following 14 days after the documented eradication of bacteremia
Number of participants with microbiological outcome 7 days after first documented positive blood culture Eradication defined as a negative follow-up blood culture \> 4 days after index blood culture
Trial Locations
- Locations (12)
University of Pittsburgh School of Medicine
🇺🇸Pittsburgh, Pennsylvania, United States
The University of Texas Health Science Center at Houston
🇺🇸Houston, Texas, United States
Hospital Sanatorio
🇦🇷Buenos Aires, Argentina
Fred Hutchinson Cancer Research Center
🇺🇸Seattle, Washington, United States
MD Anderson Cancer Center
🇺🇸Houston, Texas, United States
Jackson Health System, University of Miami Miller School of Medicine
🇺🇸Miami, Florida, United States
University of North Carolina
🇺🇸Chapel Hill, North Carolina, United States
University of Mississippi Medical Center
🇺🇸Jackson, Mississippi, United States
Hospital Universitari de Bellvitge
🇪🇸Barcelona, Spain
University of Cologne
🇩🇪Cologne, Germany
Henry Ford Hospital and Medical Centers
🇺🇸Detroit, Michigan, United States
Hospital Padre Hurtado
🇨🇱Santiago, Chile