Is amitriptyline effective in the management of chronic low back pain?

Phase 2

Completed

• Conditions: Chronic low back pain; Musculoskeletal - Other muscular and skeletal disorders

• Registration Number: ACTRN12612000131853
• Lead Sponsor: Monash University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2012-01-30
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

1. Aged 18-75 years
2. Chronic low back pain (Chronic > 3 months in duration; pain in the region bordered above by the costal margin and below by the gluteal folds)

Exclusion Criteria

- Specific pathological entities, such as infection, metastasis, osteoporosis, fractures.
- Major co-existing illness which might confound assessment of function or for which amitriptyline may be inappropriate
- Another significant musculoskeletal conditions
- History of psychosis
- Patients with any diagnosed depression with or without the use of medication
- Any prior or current use of antidepressants
- Current use of opioids
- Any contra-indication or allergy to amitriptyline
- Pregnancy or planning/trying to become pregnant or breastfeeding
- Inability to provide informed consent

Study & Design

• Study Type: Interventional
• Study Design: Not specified