The Effectiveness of Advanced Decision Support Tool (OPT-IVF) for IVF Treatment
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- total cumulative dosage of Gonadotropins
Study Overview
Brief Summary
This prospective study is subject to approval of institutional medical research ethics committee. Patient undergoing second cycle IVF will be enrolled into the intervention group. Intervention involved using a clinical decision support tool, Opt-IVF to guide gonadotrophins dosing and trigger dates for a personalized controlled ovarian stimulation cycle based on the distribution of follicle sizes on day 1 and day 5, and hormone dosages given on day 1 to 4.
Patients will undergo transvaginal ultrasound exam on day 1 and day 5 of the cycle to determine the number and size of follicles present. The data is used in the Opt-IVF decision support tool to suggest Gonadotropin dosage for D5 and beyond and to recommend the antagonist start day and trigger day.
Clinical investigators will not override the Opt-IVF recommended dosage in any patients.
Detailed Description
The total dosage of gonadotrophin, number of good quality oocytes and blastocyst will be analyzed from each arm.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 45 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Patient undergoing 2nd cycle of IVF
Exclusion Criteria
- •Polycystic ovarian syndrome patient
Outcomes
Primary Outcomes
total cumulative dosage of Gonadotropins
Time Frame: for 1 year duration
number of total dosage that utilize during one cycle of IVF treatment
Total number of matured oocytes
Time Frame: for 1 year duration
number of matured oocytes following the stimulation protocol
total number of good quality blastocyst
Time Frame: for 1 year duration
total blastocyst achieved after each sti,ulation protocol
Secondary Outcomes
No secondary outcomes reported
Investigators
Azrai Abu
Associate Prof
National University of Malaysia