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Clinical Trials/NCT03286179
NCT03286179CompletedNot Applicable

Standardizing Emergency Work-ups Around Risk Data (STEWARD): The CREST Network Chest Pain Project

Kaiser Permanente12 sites in 1 country13,419 target enrollmentStarted: July 1, 2018Last updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
13,419
Locations
12
Primary Endpoint
Major adverse cardiac event (MACE)

Study Overview

Brief Summary

Chest pain is the second leading reason for emergency department (ED) visits in the United States. Resource utilization for this ED subpopulation is particularly high, in part due to a dearth of accepted standardized clinical approaches and general overestimation of risk on the part of both providers and patients. This prospective observational cohort study seeks to address this issue by providing externally validated risk scores for major adverse cardiac events using a web-based clinical decision support platform (RISTRA) embedded within the electronic health record at 13 Kaiser Permanente Northern California (KPNC) EDs over a 12-month period. The decision support will provide risk estimates specific to the KPNC patient population. This studies hypothesis is that the provision of more accurate risk estimation for major adverse cardiac events will improve informed decision making by both providers and patients, resulting in less provocative testing and lower ED lengths of stay amongst low risk patients, as well as improving medical management among non-low risk patients and decreasing future rates of major adverse cardiac events.

Study Design

Study Type
Observational
Observational Model
Cohort
Time Perspective
Prospective

Eligibility Criteria

Ages
18 Years to — (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Emergency department chief complaint of chest pain or chest discomfort
  • Clinical concern for possible cardiac ischemia

Exclusion Criteria

  • Not provided

Outcomes

Primary Outcomes

Major adverse cardiac event (MACE)

Time Frame: 12 months

A composite outcome of either acute myocardial infarction, cardiac arrest, malignant arrhythmia, cardiac-related mortality

Secondary Outcomes

  • Provocative and anatomic cardiac testing rates(12 months)
  • Emergency department length of stay(12 months)
  • Hospital admission rate(12 months)

Investigators

Sponsor Class
Other
Responsible Party
Sponsor

Study Sites (12)

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