To assess whether a hormone called leptin which maintains healthy weightloss and increases energy expenditure is altered and to see how a 12 weeks physical activity program helps in regulating abnormal increase in leptin which is called leptin resistance in individuals with metabolic syndrome

Not Applicable

Completed

• Conditions: Health Condition 1: E889- Metabolic disorder, unspecified

• Registration Number: CTRI/2018/10/015885
• Lead Sponsor: World diabetes foundation WDF

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2021-12-31
• Last Update Posted: 17 October 2022

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 160

Inclusion Criteria

Participants with age group above 30 years to 50 years, either gender are included in the study. Participants will be included on the basis of metabolic syndrome parameters like waist circumference >94cm for males and >80cm for females, BMI >25kg/m2, fasting blood glucose >100mg/dl, blood pressure >130/85mmhg, serum triglycerides >150mg/dl, HDL <40mg/dl for males and <50 mg/dl serum leptin levels > 9.5ng/ml for males >25.0ng/ml for females, sedentary lifestyle according to GPAQ screening

Exclusion Criteria

History of smoking past 6 months, Cardiovascular disease, Stroke, TIA, Any cognitive impairment, Any recent surgeries which hinder with physical activity, Systemic illness

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Serum Leptin, Metabolic parameters ( lipid profile, fasting blood glucose, waist circumference), Quality of life ââ?¬â?? WHOQOL- BREF, GPAQ <br/ ><br>Timepoint: 3 time points <br/ ><br>1.pre-intervention -Serum Leptin, Metabolic parameters ( lipid profile, fasting blood glucose, waist circumference), Quality of life ââ?¬â?? WHOQOL- BREF, GPAQ <br/ ><br> <br/ ><br>2. post intervention (12 weeks) - all the primary outcomes <br/ ><br>3. At the end of 3 months follow up post interventon- Metabolic parameters ( lipid profile, fasting blood glucose, waist circumference), Quality of life ââ?¬â?? WHOQOL- BREF, GPAQ <br/ ><br>

Secondary Outcome Measures

Name	Time	Method
Body composition, BMR <br/ ><br>Homocysteine, Fasting Insulin <br/ ><br>Timepoint: Participants will be followed up for 3months and all the primary and secondary outcomes are assessed. Quality of life will be assessed using WHOQOL BREF questionnaire. Additional parameters like homocysteine and fasting insulin will be assessed pre and post intervention