Effect of Synbiotic Supplementation on schizophrenia symptoms

Phase 3

Recruiting

• Conditions: schizophrenia.; Schizophrenia; F20-F29

• Registration Number: IRCT20090901002394N46
• Lead Sponsor: Iran University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 70

Inclusion Criteria

Willingness to collaborate
Complete the informed consent form by the patient and the patient's guardian
Age range 18-65 years
Schizophrenia according to DSM-V criteria (By a psychiatrist)
Patients with PANSS total score = 50
Outpatient
Duration of illness less than 6 years
BMI = 23

Exclusion Criteria

Pregnancy and lactation
A history of drug or alcohol dependence or abuse
Diagnosis of mental retardation
Diagnosis of major gastrointestinal, renal, heart, cancer, HIV infection ,neurological disease or other immunodeficiency problems
Having suicidal or homicidal thoughts
Sensitivity to probiotics, prebiotic and synbiotic
Change the Dose and type of medication used during the last 2 months
Receive of Antibiotics in the last month
Consumption of probiotics, prebiotic or synbiotic over the last month
Consumption of dietary supplements in the last month

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Symptoms of schizophrenia. Timepoint: at baseline, and after 2 month. Method of measurement: PANSS scale.;Brain-derived neurotrophic factor. Timepoint: at baseline, and after 2 month. Method of measurement: Eliza.

Secondary Outcome Measures

Name	Time	Method
Anxiety and Depression Function. Timepoint: at baseline, and after 2 month. Method of measurement: Hospital Anxiety and Depression Scale.;Gastrointestinal symptoms. Timepoint: at baseline, and after 2 month. Method of measurement: GSRS Scale.;Physical activity. Timepoint: beginning and end of intervention. Method of measurement: IPAQ questionnaire.;Energy intake. Timepoint: beginning and end of intervention. Method of measurement: 24-hour food recall questionnaire.