Comparison of Standard vs. Accelerated Corneal Crosslinking

Phase 2

Recruiting

• Conditions: Ectasia Corneal; Keratoconus

• Registration Number: NCT03922542
• Lead Sponsor: Price Vision Group

Brief Summary

The study objective is to compare accelerated and standard corneal crosslinking for treatment of progressive keratoconus or corneal ectasia.

Detailed Description

Not available

Study Timeline

• Study Start: 2019-04-16
• Study First Submitted: 2019-04-17
• Study First Submitted QC: 2019-04-19
• Study First Posted: 2019-04-22
• Status Verified: 2025-07
• Last Update Submitted: 2025-07-28
• Last Update Posted: 2025-07-31
• Primary Completion: 2026-06-01
• Study Completion: 2026-07-01

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 510

Inclusion Criteria

• Documented keratoconus or ectasia after refractive surgery

Exclusion Criteria

• Insufficient corneal thickness
• Ocular condition that may predispose the eye to complications
• History of chemical injury or delayed epithelial healing
• Condition that would interfere with or prolong epithelial healing
• Known sensitivity to treatment medications
• Pregnancy

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Change in maximum keratometry	6 months	assessed by corneal tomography

Secondary Outcome Measures

Name	Time	Method
Change in uncorrected distance visual acuity	6 months	assessed with Snellen chart
Change in corrected distance visual acuity	6 months	assessed with Snellen chart

Trial Locations

Locations (1)

Price Vision Group; 🇺🇸 Indianapolis, Indiana, United States