Effect of Weight Loss on Reproductive Function in Overweight Men

• Conditions: Obesity; Overweight

• Registration Number: NCT00934765
• Lead Sponsor: Oslo University College

Brief Summary

Obesity has been found to be a risk factor for female infertility. Studies have indicated that obese men often have poor semen quality and require increased time to make partner pregnant. To date, no studies have investigated the effect of weight reduction on male fertility. The purpose of this study is to investigate the effect of weight reduction in overweight and obese men on their reproductive function.

Detailed Description

Not available

Study Timeline

• Study Start: 2008-09
• Study First Submitted: 2009-07-07
• Study First Submitted QC: 2009-07-07
• Study First Posted: 2009-07-08
• Status Verified: 2014-03
• Last Update Submitted: 2015-04-20
• Last Update Posted: 2015-04-21
• Primary Completion: 2016-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Male
• Target Recruitment: 300

Inclusion Criteria

• Age > 18
• BMI > 27 kg/m2

Exclusion Criteria

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
weight, height, % body fat, sperm (volume, concentration, motility, morphology, vitality), sperm DNA integrity, steroid hormones, gonadotropins, blood glucose, HbA1c, mCRP, lipids, adiponectins, fatty acid composition in serum and sperm phospholipids	minimum three months

Secondary Outcome Measures

Name	Time	Method
genetic variations in genes involved in metabolism and reproduction	no time frame

Trial Locations

Locations (1)

Oslo University College; 🇳🇴 Oslo, Norway